| Scavenger effect of elastase on calcifications in liver, kidney and central nervous system tissues of rabbits with atherosclerosis induced by cholesterol-rich diet. | |
| | |
MedLine Citation:
|
PMID: 2792554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The inhibitory effect of elastase on calcification in liver, kidney and the central nervous system (CNS) was studied in rabbits with atherosclerosis induced by a cholesterol-rich diet. A total of 25 male rabbits were divided into six groups. In the first three groups, rabbits received a standard diet, a 1.5% cholesterol-rich diet or a 1.5% cholesterol-rich diet with intraperitoneal elastase (450 IU/kg.day) for 3 months. In the second three groups, rabbits received a standard diet, a 0.67% cholesterol-rich diet or a 0.67% cholesterol-rich diet with intraperitoneal elastase (450 IU/kg.day) for 6 months. Tissue calcium levels were then determined by neutron activation analysis. Tissue lipid levels were also measured. Dietary cholesterol increased serum lipid levels, atherosclerotic lesions and calcium levels in the CNS, but not in the liver or kidney. Calcium levels in the cerebellum and spinal cord of rabbits receiving the 0.67% cholesterol-rich diet plus elastase were significantly lower than those of rabbits receiving the 0.67% cholesterol diet alone. Elastase had a gradual inhibitory effect on the increase in calcium levels in CNS of cholesterol-induced atherosclerotic rabbits, reduced the increase in serum lipids and decreased the incidence of atherosclerotic lesions. |
| | |
Authors:
|
M Yasui; I Yano; K Ota; A Oshima |
Related Documents
:
|
7807684 - The ace inhibitor alacepril suppresses atherogenesis independent of serum lipids in cho... 6745534 - Measurement of respiratory tract ammonia in the rabbit and implications to sulfuric aci... 11590694 - Local delivery of c-myc neutrally charged antisense oligonucleotides with transport cat... 11906114 - Influence of zinc on cardiac and serum biochemical parameters in rabbits. 15525344 - The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia a... 21889944 - High fat diet induces central obesity, insulin resistance and microvascular dysfunction... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of international medical research Volume: 17 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 1989 Jul-Aug |
Date Detail:
|
Created Date: 1989-11-22 Completed Date: 1989-11-22 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 350-7 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Wakayama Medical College, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arteriosclerosis / blood, complications, prevention & control* Calcinosis / blood, etiology, prevention & control* Calcium / blood Central Nervous System Diseases / etiology, pathology, prevention & control* Cholesterol, Dietary* Diet, Atherogenic* Injections, Intraperitoneal Kidney Diseases / etiology, pathology, prevention & control* Lipids / blood Lipoproteins, HDL / blood Liver Diseases / etiology, pathology, prevention & control* Male Pancreatic Elastase / administration & dosage, therapeutic use* Rabbits Reference Values |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, Dietary; 0/Lipids; 0/Lipoproteins, HDL; 7440-70-2/Calcium; EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of experimental diabetes on the kinetic behaviour of renal cortex hexose monophosphate deh...
Next Document: Comparison of the myotonolytic activity of tizanidine, eperisone and afloqualone in mouse and rabbit...