Document Detail

Scattered dose to thyroid from prophylactic cranial irradiation during childhood: a Monte Carlo study.
MedLine Citation:
PMID:  16585835     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to estimate the scattered dose to thyroid from prophylactic cranial irradiation during childhood. The MCNP transport code and mathematical phantoms representing the average individual at ages 3, 5, 10, 15 and 18 years old were employed to simulate cranial radiotherapy using two lateral opposed fields. The mean radiation dose received by the thyroid gland was calculated. A 10 cm thick lead block placed on the patient's couch to shield the thyroid was simulated by MCNP code. The Monte Carlo model was validated by measuring the scattered dose to the unshielded and shielded thyroid using three different humanoid phantoms and thermoluminescense dosimetry. For a cranial dose of 18 Gy, the thyroid dose obtained by Monte Carlo calculations varied from 47 to 79 cGy depending upon the age of the child. Appropriate placement of the couch block resulted in a thyroid dose reduction by 39 to 54%. Thyroid dose values at all possible positions of the radiosensitive gland with respect to the inferior field edge at five different patient ages were found. The mean difference between Monte Carlo results and thyroid dose measurements was 9.6%.
Michalis Mazonakis; Antonis Tzedakis; John Damilakis; Haris Varveris; Stefanos Kachris; Nicholas Gourtsoyiannis
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Publication Detail:
Type:  Journal Article     Date:  2006-03-30
Journal Detail:
Title:  Physics in medicine and biology     Volume:  51     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  N139-45     Citation Subset:  IM    
Department of Medical Physics, University Hospital of Iraklion, 71110 Iraklion, Crete, Greece.
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MeSH Terms
Body Burden
Brain Neoplasms / prevention & control*
Computer Simulation
Models, Biological*
Models, Statistical
Monte Carlo Method
Radiation Dosage
Radiation Injuries / etiology,  physiopathology,  prevention & control*
Radiometry / methods*
Radiotherapy / adverse effects
Relative Biological Effectiveness
Risk Assessment / methods*
Risk Factors
Scattering, Radiation
Thyroid Gland / physiopathology*,  radiation effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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