Document Detail

Scars: a review of emerging and currently available therapies.
MedLine Citation:
PMID:  18827639     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: With the investigation and potential introduction of several novel scar-reducing therapies to the market within the next several years, it is germane to review both the pathophysiology of scarring and the safety and efficacy of currently available and emerging therapeutic agents.
METHODS: An extensive review of the English-language literature was conducted using the MEDLINE database.
RESULTS: A comprehensive review of the pathophysiology of scarring and scar management, including both emerging and currently available therapies, was completed. Current clinical studies are limited by small sample sizes, lack of well-designed controls, and lack of standardized scar outcome measurement parameters.
CONCLUSIONS: A prominent challenge in the study of scar management is the paucity of well-designed, large, randomized, controlled studies examining existing scar-reducing techniques. The greatest improvement in scar-reducing protocols likely entails a polytherapeutic strategy for management. Further investigation into the role of inflammation in scarring is paramount to the development of improved scar-reducing agents. There is a need for large controlled trials using a polytherapeutic strategy that combines existing and novel agents to provide a standardized evidence-based evaluation of efficacy.
Richard G Reish; Elof Eriksson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  122     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2008-10-06     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1068-78     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Topical
Cicatrix / physiopathology*,  therapy*
Genetic Therapy
Laser Therapy
Silicone Gels / administration & dosage
Wound Healing / physiology*
Reg. No./Substance:
0/Silicone Gels
Comment In:
Plast Reconstr Surg. 2009 Jul;124(1):330   [PMID:  19568118 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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