Document Detail


Scarless wound healing in the mammalian fetus.
MedLine Citation:
PMID:  1570625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal wound healing is a remarkable process that is fundamentally different than postnatal healing. Healing of primarily closed, linear wounds occurs rapidly and without scarring. In late gestational age fetal sheep, a transition to adult-like healing occurs as evidenced by minimal scar formation. Acute inflammation is not involved, fibroblast recruitment and proliferation is minimal, the matrix of the wounds is enriched with HA and collagen deposition is highly organized so that scarring is minimal or nonexistent. Open wounds in several species do not contract, an observation that may be because of an inhibitor of contraction in amniotic fluid. The underlying mechanisms that regulate fetal wound repair are currently not well understood. An altered supply or activity of growth factors may be instrumental. Fibroblasts may preferentially produce HA secondary to a factor present within the fetal system, and HA may influence cellular and matrix events within the wound. As greater knowledge of the biologic factors of scarless healing in the fetus is gained, applications to abnormal adult healing may be developed. As the age of fetal surgery is approaching, it is essential to understand the injury response in these new patients.
Authors:
B A Mast; R F Diegelmann; T M Krummel; I K Cohen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  174     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-28     Completed Date:  1992-05-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-51     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Medical College of Virginia, Richmond 23298-0154.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid / physiology
Animals
Burns / pathology,  physiopathology
Cell Differentiation
Cicatrix
Fetus / immunology,  physiology*,  surgery
Gestational Age
Haplorhini
Humans
Hyaluronic Acid / physiology
Rabbits
Rats
Regeneration
Sheep
Time Factors
Wound Healing*
Grant Support
ID/Acronym/Agency:
GM 20298/GM/NIGMS NIH HHS; GM 41343/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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