Document Detail


Scarless fetal wound healing: a basic science review.
MedLine Citation:
PMID:  20885241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Scar formation is a major medical problem that can have devastating consequences for patients. The adverse physiological and psychological effects of scars are broad, and there are currently no reliable treatments to prevent scarring. In contrast to adult wounds, early gestation fetal skin wounds repair rapidly and in the absence of scar formation. Despite extensive investigation, the exact mechanisms of scarless fetal wound healing remain largely unknown. For some time, it has been known that significant differences exist among the extracellular matrix, inflammatory response, cellular mediators, and gene expression profiles of fetal and postnatal wounds. These differences may have important implications in scarless wound repair.
Authors:
Barrett J Larson; Michael T Longaker; H Peter Lorenz
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  126     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-12-10     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1172-80     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Blastocyst Inner Cell Mass / cytology,  physiology
Cell Transdifferentiation*
Cicatrix / prevention & control*
Embryonic Stem Cells / cytology*,  physiology
Fetus / metabolism,  physiology*
Forecasting
Humans
Research Design / trends
Science
Stem Cell Transplantation
Wound Healing / physiology*
Grant Support
ID/Acronym/Agency:
R01 GM087609/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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