| Scarless fetal wound healing: a basic science review. | |
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MedLine Citation:
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PMID: 20885241 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SUMMARY: Scar formation is a major medical problem that can have devastating consequences for patients. The adverse physiological and psychological effects of scars are broad, and there are currently no reliable treatments to prevent scarring. In contrast to adult wounds, early gestation fetal skin wounds repair rapidly and in the absence of scar formation. Despite extensive investigation, the exact mechanisms of scarless fetal wound healing remain largely unknown. For some time, it has been known that significant differences exist among the extracellular matrix, inflammatory response, cellular mediators, and gene expression profiles of fetal and postnatal wounds. These differences may have important implications in scarless wound repair. |
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Authors:
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Barrett J Larson; Michael T Longaker; H Peter Lorenz |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Plastic and reconstructive surgery Volume: 126 ISSN: 1529-4242 ISO Abbreviation: Plast. Reconstr. Surg. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-12-10 Revised Date: 2012-02-20 |
Medline Journal Info:
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Nlm Unique ID: 1306050 Medline TA: Plast Reconstr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1172-80 Citation Subset: AIM; IM |
Affiliation:
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Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blastocyst Inner Cell Mass
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cytology,
physiology Cell Transdifferentiation* Cicatrix / prevention & control* Embryonic Stem Cells / cytology*, physiology Fetus / metabolism, physiology* Forecasting Humans Research Design / trends Science Stem Cell Transplantation Wound Healing / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM087609-05/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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