Document Detail


Scarless fetal skin wound healing update.
MedLine Citation:
PMID:  23109319     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Scar formation, a physiologic process in adult wound healing, can have devastating effects for patients; a multitude of pathologic outcomes, affecting all organ systems, stems from an amplification of this process. In contrast to adult wound repair, the early-gestation fetal skin wound heals without scar formation, a phenomenon that appears to be intrinsic to fetal skin. An intensive research effort has focused on unraveling the mechanisms that underlie scarless fetal wound healing in an attempt to improve the quality of healing in both children and adults. Unique properties of fetal cells, extracellular matrix, cytokine profile, and gene expression contribute to this scarless repair. Despite the great increase in knowledge gained over the past decades, the precise mechanisms regulating scarless fetal healing remain unknown. Herein, we describe the current proposed mechanisms underlying fetal scarless wound healing in an effort to recapitulate the fetal phenotype in the postnatal environment. Birth Defects Research (Part C) 96:237-247, 2012. © 2012 Wiley Periodicals, Inc.
Authors:
David D Lo; Andrew S Zimmermann; Allison Nauta; Michael T Longaker; H Peter Lorenz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Birth defects research. Part C, Embryo today : reviews     Volume:  96     ISSN:  1542-9768     ISO Abbreviation:  Birth Defects Res. C Embryo Today     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167665     Medline TA:  Birth Defects Res C Embryo Today     Country:  United States    
Other Details:
Languages:  eng     Pagination:  237-47     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Surgery, Hagey Laboratory for Pediatric Regenerative Medicine, Stanford, California; Department of Surgery, Duke University Medical Center, Durham, North Carolina.
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