Document Detail

Scar Characteristics for Prediction of Ventricular Arrhythmia in Ischemic Cardiomyopathy.
MedLine Citation:
PMID:  25431107     Owner:  NLM     Status:  Publisher    
BACKGROUND: Better risk-stratification tools are needed to identify the best candidates for implantable cardioverter defibrillator implantation. Infarct characterization by cardiac magnetic resonance (CMR) has become an evolving potential tool for risk stratification.
OBJECTIVE: We assessed the ability of scar characteristics by CMR in patients with postinfarction left ventricular (LV) dysfunction to predict sustained monomorphic ventricular tachycardia (SMVT).
METHODS: Forty-eight patients with postinfarction LV dysfunction underwent CMR study. Twenty-four patients had history of SMVT and the other 24 were control group and underwent electrophysiological study to assess SMVT inducibilty. Various scar characteristics were assessed in the spontaneous SMVT group and were compared with the inducible and noninducible SMVT groups.
RESULTS: Only six patients in the control group had inducible SMVT. In univariable analysis, total scar (absolute and as percent of LV), scar core (absolute and as percent of LV), peri-infarct zone (absolute and as percent of LV), mean infarct transmurality, and number of segments with late gadolinium enhancement (LGE) were statistically significant predictors of spontaneous SMVT experience and SMVT inducibility. In multivariable analysis, total infarct as percent of LV mass was the only significant independent predictor of spontaneous SMVT experience (odds ratio [OR] 1.33 per% change, 95% confidence interval [CI] 1.12-1.6, P = 0.001) and SMVT inducibility (OR 1.3 per% change, 95% CI 1.1-1.6, P = 0.004).
CONCLUSION: Characterization of myocardial infarct by LGE-CMR, specifically total infarct size, is better predictor of spontaneous SMVT experience and SMVT inducibility than LV ejection fraction.
Sherif Gouda; Amir Abdel Wahab; Mohamed Salem; Magdy Abdel Hamid
Related Documents :
15249167 - Vasopressin effects on the coronary circulation after a short ischemia in anesthetized ...
2929397 - Protective effect of the specific thromboxane receptor antagonist, bm-13505, in reperfu...
8067547 - The effects of isoflurane on regional myocardial contractility and metabolism in "stunn...
25382137 - The clinical challenge of preventing sudden cardiac death immediately after acute st-el...
16231627 - Extracorporeal membrane oxygenation to cardiopulmonary bypass with a single circuit exp...
15272897 - The screening for x-linked emery-dreifuss muscular dystrophy amongst young patients wit...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-27
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  -     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-28     Completed Date:  -     Revised Date:  2014-11-29    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 Wiley Periodicals, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Review: minimally invasive strabismus surgery.
Next Document:  Long-term entecavir or tenofovir disoproxil fumarate therapy in treatment-naïve chronic hepatitis B ...