Document Detail

Scanning laser polarimetry of the retinal nerve fiber layer in perimetrically unaffected eyes of glaucoma patients.
MedLine Citation:
PMID:  15582074     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare scanning laser polarimetry (SLP) measurements of retinal nerve fiber layer (RNFL) thickness in perimetrically unaffected eyes of glaucoma patients with those in their fellow eyes with field loss and eyes of healthy subjects. DESIGN: Observational case-control study. PARTICIPANTS AND CONTROLS: Twenty-three glaucoma patients with a reproducible visual field (VF) defect in one eye (mean mean deviation [MD], -5.71 decibels [dB]) and a normal VF in the other one (i.e., < or =1 VF test point below the 5% probability level [mean MD, -0.01 dB]) and 73 control eyes of as many age-matched healthy subjects (mean MD, 0.39 dB). The MDs and pattern standard deviations of the glaucoma patients' eyes with normal VFs and the control eyes did not statistically significantly differ (independent samples t test, P = 0.15 and P = 0.61, respectively). METHODS: All subjects were measured in both eyes with the GDxVCC, a commercially available instrument featuring SLP with automated variable corneal compensation. Standard automated perimetry was assessed by means of the Humphrey Field Analyzer (24-2 Full Threshold or Swedish interactive threshold algorithm Standard achromatic test program). MAIN OUTCOME MEASURES: The standard GDxVCC parameters TSNIT (temporal, superior, nasal, inferior, temporal) Average, Superior Average, Inferior Average, TSNIT Std. Dev., and Nerve Fiber Indicator (NFI) were determined. We also assessed the thickness values in 6 parapapillary sectors. In addition, we calculated the proportion of eyes per group with an NFI of > or =40. RESULTS: GDxVCC measurements showed more RNFL thinning in the perimetrically unaffected eyes of glaucoma patients than in the healthy control eyes. The RNFL in the perimetrically unaffected eyes of glaucoma patients was thicker than that in their fellow eyes with field loss. The NFI had a value of > or =40 in 11 of 23 (47.8%) perimetrically unaffected eyes of glaucoma patients, 19 of 23 (82.6%) eyes with VF loss of glaucoma patients, and 3 of 73 (4.1%) healthy control eyes. CONCLUSION: With the GDxVCC, thinning of the RNFL may be detected in perimetrically unaffected eyes of glaucoma patients with field loss in their fellow eyes.
Nicolaas J Reus; Hans G Lemij
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ophthalmology     Volume:  111     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-07     Completed Date:  2004-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2199-203     Citation Subset:  IM    
Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Diagnostic Techniques, Ophthalmological
Glaucoma, Open-Angle / diagnosis*
Intraocular Pressure
Lasers / diagnostic use
Middle Aged
Nerve Fibers / pathology*
Optic Nerve Diseases / diagnosis*
Retinal Ganglion Cells / pathology*
Tonometry, Ocular
Vision Disorders / diagnosis*
Visual Fields*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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