Document Detail

Scanning electron microscopic studies on the subepithelial tissue of the gastrointestinal mucosa of the rat.
MedLine Citation:
PMID:  2505827     Owner:  NLM     Status:  MEDLINE    
The three-dimensional architecture of the subepithelial tissue of the gastric, the small and the large intestinal mucosa of the rat was observed by scanning electron microscopy (SEM) after removal of cellular elements through prolonged osmication followed by ultrasonication (the method by Highison and Low, 1982), or by cell-maceration with a low temperature NaOH solution (the method by Ohtani, 1987). The basal lamina was exposed by the former method, and the collagenous fibrous sheet immediately under the basal lamina was disclosed by the latter. The surface of the subepithelial tissue is grossly smooth in the pyloric gland and crypts of the small and the large intestine. However, in the fundic glands of the stomach, the surface structure of the subepithelial tissue greatly differs according to glandular location. In the pit of the fundic glands, the surface of both the basal lamina and the sub-basal laminar fibrous sheet is smooth. In the neck region, however, shallow round depressions are seen. The most striking feature of the subepithelial tissue of the fundic glands is the presence of numerous hemispherical concavities in the middle and basal regions of the glands which harbor parietal cells. On the surface of the small intestinal villi, the basal lamina is elevated by the underlying capillary network and forms a meshwork of ridges that surround shallow basins in which numerous round fenestrations 1-5 microns in diameter are seen. The fibrous sheath of the marginal arteriole is observed as a cord-like protuberance on the apical margin of the villi; this suggests its role in the maintenance of the structural integrity of the villi. In the large intestine, well defined round fenestrations are clearly seen, mainly distributed on the upper third of the crypts, and continuing to the lamina propria.
T Sugimoto; T Ogata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of histology and cytology     Volume:  52     ISSN:  0914-9465     ISO Abbreviation:  Arch. Histol. Cytol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-20     Completed Date:  1989-10-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8806082     Medline TA:  Arch Histol Cytol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  257-65     Citation Subset:  IM    
Department of Surgery, Kochi Medical School, Japan.
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MeSH Terms
Epithelium / ultrastructure
Gastric Mucosa / ultrastructure*
Intestinal Mucosa / ultrastructure*
Intestine, Large / ultrastructure
Intestine, Small / ultrastructure
Microscopy, Electron, Scanning
Rats, Inbred Strains
Sodium Hydroxide
Reg. No./Substance:
1310-73-2/Sodium Hydroxide

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