Document Detail

Scaling characteristics of heart rate time series before the onset of ventricular tachycardia.
MedLine Citation:
PMID:  17171301     Owner:  NLM     Status:  MEDLINE    
Ventricular tachycardia (VT) provokes sudden cardiac death (SCD), which is a major cause of mortality in developed countries. Implantable cardioverter-defibrillators (ICDs) are an efficient therapy for SCD prevention. In this study we analyze heart rate variability (HRV) in data stored by ICDs. In 29 patients exhibiting VT episodes, the last 1000 normal beat-to-beat intervals are analyzed and compared to an individually acquired control time series (CON). HRV analysis is performed with standard parameters of time and frequency domain as suggested by the HRV Task Force. For scaling analyses of heart rate time series, the fractal dimension is analysed, applying Higuchi's algorithm (HFD). Furthermore, detrended fluctuation analysis (DFA) is performed. None of the standard HRV parameters shows significant differences between CON and VT. Before the onset of VT, the scaling characteristics by means of HFD and DFA are significantly changed. In conclusion, scaling analysis reveals changes in autonomic heart rate modulation preceding VT.
Mathias Baumert; Niels Wessel; Alexander Schirdewan; Andreas Voss; Derek Abbott
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-14
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  35     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-03-20     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
Centre for Biomedical Engineering (CBME), The University of Adelaide, Adelaide, SA 5005, Australia.
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MeSH Terms
Diagnosis, Computer-Assisted / methods*
Electrocardiography / methods*
Heart Failure / complications,  diagnosis*,  physiopathology*
Heart Rate*
Reproducibility of Results
Sensitivity and Specificity
Tachycardia, Ventricular / diagnosis*,  etiology,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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