| Scaling of the BMP activation gradient in Xenopus embryos. | |
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MedLine Citation:
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PMID: 18580943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In groundbreaking experiments, Hans Spemann demonstrated that the dorsal part of the amphibian embryo can generate a well-proportioned tadpole, and that a small group of dorsal cells, the 'organizer', can induce a complete and well-proportioned twinned axis when transplanted into a host embryo. Key to organizer function is the localized secretion of inhibitors of bone morphogenetic protein (BMP), which defines a graded BMP activation profile. Although the central proteins involved in shaping this gradient are well characterized, their integrated function, and in particular how pattern scales with size, is not understood. Here we present evidence that in Xenopus, the BMP activity gradient is defined by a 'shuttling-based' mechanism, whereby the BMP ligands are translocated ventrally through their association with the BMP inhibitor Chordin. This shuttling, with feedback repression of the BMP ligand Admp, offers a quantitative explanation to Spemann's observations, and accounts naturally for the scaling of embryo pattern with its size. |
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Authors:
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Danny Ben-Zvi; Ben-Zion Shilo; Abraham Fainsod; Naama Barkai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature Volume: 453 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-26 Completed Date: 2008-08-07 Revised Date: 2009-09-04 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 1205-11 Citation Subset: IM |
Affiliation:
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Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning Body Size Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins / antagonists & inhibitors, metabolism* Embryo, Nonmammalian / embryology, metabolism* Glycoproteins / metabolism Intercellular Signaling Peptides and Proteins / metabolism Ligands Models, Biological Protein Transport Xenopus / embryology*, genetics, metabolism Xenopus Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Proteins; 0/Glycoproteins; 0/Intercellular Signaling Peptides and Proteins; 0/Ligands; 0/Xenopus Proteins; 0/admp protein, Xenopus; 0/bmp4 protein, Xenopus; 93586-27-7/chordin |
| Comments/Corrections | |
Comment In:
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Nature. 2009 Sep 3;461(7260):E1; discussion E2
[PMID:
19736667
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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