| Scale-up of cell culture bioreactors using biomechatronic design. | |
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MedLine Citation:
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PMID: 22396305 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Scale-up of cell culture bioreactors is a challenging engineering work that requires wide competence in cell biology, mechanical engineering and bioprocess design. In this article, a new approach for cell culture bioreactor scale-up is suggested that is based on biomechatronic design methodology. The approach differs from traditional biochemical engineering methodology by applying a sequential design procedure where the needs of the users and alternative design solutions are systematically analysed. The procedure is based on the biological and technical functions of the scaled-up bioreactor that are derived in functional maps, concept generation charts and scoring and interaction matrices. Basic reactor engineering properties, such mass and heat transfer and kinetics are integrated in the procedure. The methodology results in the generation of alternative design solutions that are thoroughly ranked with help of the user needs. Examples from monoclonal antibody and recombinant protein illuminate the steps of the procedure. The methodology provides engineering teams with additional tools that can significantly facilitate the design of new production methods for cell culture processes. |
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Authors:
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Carl-Fredrik Mandenius; Mats Björkman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-7 |
Journal Detail:
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Title: Biotechnology journal Volume: - ISSN: 1860-7314 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265833 Medline TA: Biotechnol J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Division of Biotechnology/IFM, Linköping University, Linköping, Sweden. cfm@ifm.liu.se. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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