| Scale exponents of blood pressure and heart rate during autonomic blockade as assessed by detrended fluctuation analysis. | |
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MedLine Citation:
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PMID: 21115648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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How the autonomic nervous system influences the fractal dynamics of heart rate (HR) and blood pressure (BP) remains unclear. The purpose of our study was to separately assess cardiac vagal and sympathetic (cardiac vs. vascular) influences on fractal properties of HR and BP as described by scale exponents of detrended fluctuation analysis (DFA). R-R intervals, systolic and diastolic BP were measured in nine supine volunteers before and after administration of autonomic blocking agents (atropine, propranolol, atropine+propranolol, clonidine). Spectra of DFA scale exponents, α(t), were calculated for scales between 5 and 100 s. HR and BP scale structures differed at baseline, being α(t) of HR <1, with a minimum between 10 and 20 s followed by a higher plateau between 40 to 80 s, while α(t) of BP decreased with t from values >1. Comparison of atropine and propranolol with baseline and combined cardiac parasympathetic and sympathetic blockade (atropine+propranolol) indicated opposite influences of vagal and cardiac sympathetic outflows on HR exponents. The vagal outflow adds white-noise components, amplifying differences with BP exponents; the cardiac sympathetic outflow adds Brownian motion components at short scales and contributes to the plateau between 40 and 80 s. Overall sympathetic inhibition by clonidine decreased short- and long-term exponents of HR, and short-term exponents of BP, so that their α(t) spectra had different means but similar profiles. Therefore, cardiac vagal, cardiac sympathetic and vascular sympathetic outflows contribute differently to HR and BP fractal structures. Results are explained by different distribution and dynamics of acetylcholine receptors and of α- and β-adrenergic receptors between heart and vasculature. |
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Authors:
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Paolo Castiglioni; Gianfranco Parati; Marco Di Rienzo; Roberta Carabalona; Andrei Cividjian; Luc Quintin |
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Publication Detail:
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Type: Journal Article Date: 2010-11-29 |
Journal Detail:
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Title: The Journal of physiology Volume: 589 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-17 Completed Date: 2011-05-25 Revised Date: 2012-01-16 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 355-69 Citation Subset: IM |
Affiliation:
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Polo Tecnologico, Fondazione Don C. Gnocchi, Milano, Italy. pcastiglioni@dongnocchi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atropine / pharmacology Autonomic Nervous System / drug effects, physiology* Blood Pressure / drug effects, physiology* Clonidine / pharmacology Electrocardiography Fractals Heart / drug effects, physiology Heart Rate / drug effects, physiology* Humans Male Middle Aged Parasympatholytics / pharmacology Propranolol / pharmacology Supine Position Sympatholytics / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Parasympatholytics; 0/Sympatholytics; 4205-90-7/Clonidine; 51-55-8/Atropine; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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