| Scaffold modeling application in the repair of skull defects. | |
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MedLine Citation:
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PMID: 19663864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The repair of large segmental bone defects caused by trauma, inflammation, and surgery on tumors pose a major clinical challenge. Tissue-engineered bone is emerging as a good choice for prefabricating cellular scaffold, and computer-aided technologies and medical imaging have created new possibilities in biomedical engineering. An accurate and efficient construction of anatomic models is critical to the application of these computational methods. Such models must be validated prior to application. In this article, we explore the potential of combining these techniques to scaffold and repair a pediatric skull. Working under the hypothesis that the autogenously cultivated osteoblasts can be grown on individualized scaffolds to improve bone regeneration in skull defects, we focus our study on potential problems concerning the segmentation, reconstruction, and mesh simplification for a pediatric skull. We also propose a new framework to improve the accuracy of the model entity from image segmentation to mesh simplification. |
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Authors:
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Weibing Wan; Pengfei Shi |
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Publication Detail:
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Type: Journal Article Date: 2009-08-07 |
Journal Detail:
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Title: Artificial organs Volume: 34 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 339-42 Citation Subset: IM |
Affiliation:
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Institute of Image Processing and Pattern Recognition, Shanghai Jiaotong University, Shanghai, China. wbwan@sjtu.edu.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Regeneration Bone Substitutes Bone Transplantation / methods* Bone and Bones / surgery* Child Female Humans Imaging, Three-Dimensional Models, Anatomic Osteoblasts Skull / injuries, surgery* Tissue Engineering / methods* Tissue Scaffolds* |
| Chemical | |
Reg. No./Substance:
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0/Bone Substitutes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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