Document Detail


Scab incidence on pig skin resulting from hot particle exposures under varying conditions.
MedLine Citation:
PMID:  11414624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
External irradiations of pig skin using radioactive sources of less than 600 microm in the largest dimension (hot particles) were carried out. The objective of the study was to determine a threshold for scab induction. Hot particles used included fissioned 235U and activated 170Tm, 17SYb, and 46Sc with maximum beta-particle energies of approximately 1.8 (average), 0.97, 0.47, and 0.35 MeV, respectively. The photon emissions from the fissioned 235U were about 1 MeV per disintegration. The photon emissions from 46Sc were 0.89 and 1.12 MeV, with 100% abundance. Photon emissions from 170Tm and 175Yb were negligible. Responses followed cumulative normal probability distributions; thus, no true thresholds could be determined. Hence, 10% and 50% scab incidence rates (ED10 and ED50, respectively) were determined using probit analysis. For dose averaged over 1 cm2 at a depth of 70 microm, the ED10 (and 95% confidence limits) were 5.1 (2.7-7.2) Gy for 46Sc, 1.3 (0.89-1.8) Gy for 175Yb, 2.8 (1.9-3.5) Gy for 170Tm, 8.5 (5.7-9.8) Gy for on-skin fissioned UC2, and 4.5 (0.9-7.2) Gy for off-skin fissioned UC2. The ED50 values were 12 (8.8-17) Gy for 46Sc, 6.0 (4.3-9.7) Gy for 175Yb, 5.9 (5.1-6.7) Gy for 170Tm, 11 (9.9-19) Gy for on-skin fissioned 235UC2, and 11 (6.2-14) Gy for off-skin fissioned 235UC2.
Authors:
D G Kaurin; J W Baum; A L Carsten; C W Schaefer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Health physics     Volume:  81     ISSN:  0017-9078     ISO Abbreviation:  Health Phys     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-20     Completed Date:  2001-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-56     Citation Subset:  IM    
Affiliation:
Department of Advanced Technology, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. darryl.kaurin@mcmail.vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Radiation
Incidence
Radiation Injuries / pathology*
Skin / pathology*,  radiation effects*
Swine

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