| Saxagliptin and Sitagliptin in adult patients with type 2 diabetes: a systematic review and meta-analysis. | |
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MedLine Citation:
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PMID: 22098472 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To compare the efficacy and safety of sitagliptin and saxagliptin with placebo and other hypoglycemic medications in adults with type 2 diabetes. Research Design & Methods: We searched MEDLINE(®) , Embase, the Cochrane Library, and the International Pharmaceutical Abstracts from their inception through February 3, 2011. Studies were included of adults with type 2 diabetes that were 12 weeks or more in duration. Meta-analyses were conducted when included studies were homogenous enough to justify combining their results. Results: 32 articles met inclusion criteria. Sitagliptin 100mg monotherapy and saxagliptin 5mg resulted in greater HbA1c reduction compared to placebo (WMD -0.82%, 95% CI -0.95 to -0.70 and WMD -0.70, 95% CI -0.84 to -0.56, respectively). Sitagliptin was similar to sulfonylureas for HbA1c reduction (WMD 0.08%, 95% CI 0-0.16, 3 trials), and to saxagliptin in 1 head-to-head trial. There was no statistically significant difference in hypoglycemia between sitagliptin (pooled RR 1.55, 95% CI 0.55-4.36) or saxagliptin (pooled RR 1.04, 95% CI 0.28 to 3.81) and placebo. Conclusion: Sitagliptin and saxagliptin result in similar modest HbA1c reductions and do not increase the risk of hypoglycemia unless combined with other therapies. Their role in the long term treatment of type 2 diabetes remains unclear given the lack of long-term data on efficacy, harms, and health outcomes. |
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Authors:
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Katherine R Gerrald; Erin Van Scoyoc; Roberta C Wines; Thomas Runge; Daniel E Jonas |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-19 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Presbyterian College School of Pharmacy, Clinton, SC Brown Alpert Medical School, Department of Pediatrics, Providence, RI RTI-UNC Evidence-based Practice Center, Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC University of North Carolina, School of Medicine, Chapel Hill, NC University of North Carolina, Department of Medicine, Chapel Hill, NC Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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