| Sauvagine: effects on thermoregulation in the rat. | |
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MedLine Citation:
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PMID: 2330343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sauvagine is a 40 amino acid peptide, isolated from the skin of the South American frog, Phyllomedusa sauvagei, and structurally related to mammalian corticotropin releasing factor (CRF). Experiments with centrally or peripherally injected sauvagine produced dose-dependent hypothermia in rats kept at ambient temperatures of +4 degrees C and +22 degrees C, but no effect was seen on rats maintained at +34 degrees C. To determine whether a pituitary-adrenal dependent step was involved, the thermoregulatory response was studied in hypophysectomized, adrenalectomized and sham-operated rats maintained at a room temperature of +22 degrees C. Significant hypothermia was produced in all three experimental groups, showing that this response is not mediate by the pituitary-adrenal axis. CRF had no effect on the thermoregulatory functions of rats and furthermore alpha-helical CRF (9-41), a CRF receptor antagonist, which inhibited the pituitary and cardiovascular actions of sauvagine, did not modify the thermoregulatory response in rats. |
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Authors:
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M Broccardo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 22 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 1990 Mar-Apr |
Date Detail:
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Created Date: 1990-05-30 Completed Date: 1990-05-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 189-96 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology, University La Sapienza, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Amphibian Proteins Animals Blood Pressure / drug effects Body Temperature Regulation / drug effects* Corticotropin-Releasing Hormone / administration & dosage, pharmacology Heart Rate / drug effects Hypophysectomy Injections, Intraventricular Injections, Subcutaneous Male Peptide Hormones Peptides / administration & dosage, pharmacology* Pituitary-Adrenal System / physiology Rats Rats, Inbred Strains Vasodilator Agents / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Amphibian Proteins; 0/Peptide Hormones; 0/Peptides; 0/Vasodilator Agents; 74434-59-6/sauvagine; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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