Document Detail


Saturated and trans fatty acids and coronary heart disease.
MedLine Citation:
PMID:  18937892     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary intake of both saturated and trans fatty acids has been associated with an increase in the risk of coronary heart disease (CHD). Evidence comes mainly from controlled dietary experiments with intermediate end points, such as blood lipoproteins, and from observational studies. A few small, randomized controlled trials with clinical end points have been carried out in which saturated fat was replaced with polyunsaturated fat, leading to a reduction in low-density lipoprotein cholesterol and a reduction in CHD risk. However, no such studies exist for trans fatty acids. More high-quality, randomized controlled trials on fatty acids and CHD are required, but public health recommendations to reduce intake of both saturated and trans fatty acids are appropriate based on the current evidence.
Authors:
Jayne V Woodside; Michelle C McKinley; Ian S Young
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  10     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2009-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  460-6     Citation Subset:  IM    
Affiliation:
Nutrition and Metabolism Group, Centre for Clinical and Population Science, Queen's University Belfast, Lower Ground Floor, Pathology Building, Grosvenor Road, Belfast, BT12 6BJ, UK. j.woodside@qub.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Coronary Disease / etiology*
Dietary Fats / adverse effects*
Fatty Acids / adverse effects*
Humans
Trans Fatty Acids / adverse effects*
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Trans Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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