| Saturated and trans fatty acids and coronary heart disease. | |
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MedLine Citation:
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PMID: 18937892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary intake of both saturated and trans fatty acids has been associated with an increase in the risk of coronary heart disease (CHD). Evidence comes mainly from controlled dietary experiments with intermediate end points, such as blood lipoproteins, and from observational studies. A few small, randomized controlled trials with clinical end points have been carried out in which saturated fat was replaced with polyunsaturated fat, leading to a reduction in low-density lipoprotein cholesterol and a reduction in CHD risk. However, no such studies exist for trans fatty acids. More high-quality, randomized controlled trials on fatty acids and CHD are required, but public health recommendations to reduce intake of both saturated and trans fatty acids are appropriate based on the current evidence. |
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Authors:
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Jayne V Woodside; Michelle C McKinley; Ian S Young |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 10 ISSN: 1534-6242 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2009-01-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 460-6 Citation Subset: IM |
Affiliation:
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Nutrition and Metabolism Group, Centre for Clinical and Population Science, Queen's University Belfast, Lower Ground Floor, Pathology Building, Grosvenor Road, Belfast, BT12 6BJ, UK. j.woodside@qub.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Disease
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etiology* Dietary Fats / adverse effects* Fatty Acids / adverse effects* Humans Trans Fatty Acids / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Trans Fatty Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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