Document Detail


Saturated phospholipids in amniotic fluid of normal and diabetic pregnancies.
MedLine Citation:
PMID:  6547519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess fetal lung maturation in normal and diabetic pregnancies, the authors studied two phospholipids that are more specific for pulmonary surfactant than total phosphatidylcholine (lecithin), namely saturated phosphatidylcholine and phosphatidylglycerol. Results indicated that saturated phosphatidylcholine concentrations normally increase from 10 to 20 nmol/mL before 34 weeks to as high as 150 nmol/mL at term. Although the absolute concentration of saturated phosphatidylcholine could not be used to reliably identify pregnancies leading to respiratory distress syndrome, a saturated phosphatidylcholine level greater than 50% of total phosphatidylcholine was associated with satisfactory neonatal pulmonary function, whereas RDS often occurred in premature infants when less than half the phosphatidylcholine was saturated. Carefully regulated diabetic pregnancies at 36 to 42 weeks of gestation were not different from matched control subjects with respect to total phosphatidylcholine, its ratio to sphingomyelin, saturated phosphatidylcholine, or phosphatidylglycerol. Respiratory distress syndrome did not occur in any infant of the 40 diabetic mothers studied, nor were there any congenital anomalies or cases of symptomatic hypoglycemia.
Authors:
P M Farrell; M J Engle; L B Curet; R H Perelman; J C Morrison
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  64     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-07-27     Completed Date:  1984-07-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-85     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / analysis*
Female
Fetal Organ Maturity
Humans
Infant, Newborn
Lung / embryology
Phosphatidylcholines / analysis*
Phosphatidylglycerols / analysis*
Pregnancy
Pregnancy in Diabetics / metabolism*
Respiratory Distress Syndrome, Newborn / diagnosis
Grant Support
ID/Acronym/Agency:
HD00350/HD/NICHD NIH HHS; HD11429/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phosphatidylglycerols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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