| Saturable transport of cimetidine from cerebrospinal fluid to blood in rats. | |
| | |
MedLine Citation:
|
PMID: 4009399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cimetidine, a histamine H2 receptor antagonist, is known to have some effects on central nervous system, and is reported to emerge in the cerebrospinal fluid (CSF). We evaluated the elimination of cimetidine from CSF by the method of ventriculo-cisternal perfusion in rats. The extraction ratio of cimetidine at the low perfusate concentration (14 nM) was 0.190 +/- 0.023 (n = 3), while that significantly (p less than 0.02) decreased to 0.0916 +/- 0.081 (n = 3) at the high concentration (4 mM). No significant difference was observed in the production rate of CSF between these two concentrations. These findings suggest that cimetidine is excreted from CSF to blood by a saturable transport system. |
| | |
Authors:
|
H Suzuki; Y Sawada; Y Sugiyama; T Iga; M Hanano |
Related Documents
:
|
15374109 - The elimination of aged glycoproteins by the isolated perfused rat liver. 6205639 - Structure-function relationships of protoporphyrin-induced liver injury. 3722809 - Biliary excretion of 110mag and its kinetics in the isolated perfused liver in rats. 6546449 - Intrathecal chronic catheterization in the rat. 3994679 - Rapid thyroid-hormone effect on mitochondrial and cytosolic atp/adp ratios in the intac... 433519 - Liver cirrhosis and oestrogen metabolism--perfusion studies with cirrhotic rat livers. 1211909 - Bacampicillin: a new orally well-absorbed derivative of ampicillin. 9287399 - The characterization of reconstituted passenger leukocytes on the induction of toleranc... 11714499 - Persistence of meal-entrained circadian rhythms following area postrema lesions in the ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pharmacobio-dynamics Volume: 8 ISSN: 0386-846X ISO Abbreviation: J. Pharmacobio-dyn. Publication Date: 1985 Jan |
Date Detail:
|
Created Date: 1985-07-31 Completed Date: 1985-07-31 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7901854 Medline TA: J Pharmacobiodyn Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 73-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Transport Cimetidine / blood, cerebrospinal fluid, metabolism* Male Perfusion Rats Rats, Inbred Strains Tritium / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
10028-17-8/Tritium; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A simple and rapid method for preparation of 203Hg-labeled methylmercury from 203HgCl2 and methylcob...
Next Document: Toxicity of local anaesthetics on myogenic cells in culture.