| Satisfactory outcome despite low 2-hour postdose cyclosporine level in Iranian kidney recipients. | |
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MedLine Citation:
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PMID: 19377217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Cyclosporine has a narrow therapeutic serum level in kidney transplantation. Achieving the recommended therapeutic levels is necessary, but in different ethnic groups, the impact of the cyclosporine level on patient and graft survival has not been fully addressed yet. We investigated this issue by studying the 2-hour postdose serum concentration of cyclosporine (C2) and the long-term graft and patient survival in Iranian transplant recipients. MATERIALS AND METHODS: A total of 397 kidney recipients were evaluated for the C2 serum levels. All patients were under treatment with prednisolone, mycophenolate mofetil, and cyclosporine (Neoral). Measurements C2 were considered at different time intervals: the first 2 months, 2 to 6 months, and after 6 months posttransplantation. The mean of C2 levels at specified intervals were evaluated and compared with the recommended optimal ranges. Patient and graft survival rate were also calculated. RESULTS: In the studied patients, C2 levels were lower than the upper recommended range in 96.9%, 83.6% and 64.5% in the first 2 months, between 2 and 6 months, and after 6 months posttransplantation, respectively. The overall 5-year patient and graft survival rates were 95% and 85%, respectively. CONCLUSIONS: Despite the fact that the majority of the patients had C2 levels lower than the recommended values, we observed good patient and graft survival rates. Our data suggests that different populations may need different target levels definition. |
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Authors:
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Vahid Pourfarziani; Eqlim Nemati; Saeed Taheri; Hamid Reza Khoddami-Vishte; Mehdi Azizabadi Farahani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Iranian journal of kidney diseases Volume: 2 ISSN: 1735-8582 ISO Abbreviation: Iran J Kidney Dis Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2009-04-20 Completed Date: 2009-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316967 Medline TA: Iran J Kidney Dis Country: Iran |
Other Details:
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Languages: eng Pagination: 99-101 Citation Subset: IM |
Affiliation:
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Kidney Transplant Department, Baqiyatallah University of Medical Sciences, Tehran, Iran. cru.common@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cyclosporine / administration & dosage* Dose-Response Relationship, Drug Drug Monitoring Drug Therapy, Combination Female Graft Survival* Humans Immunosuppressive Agents / administration & dosage* Kidney Transplantation* Male Middle Aged Mycophenolic Acid / analogs & derivatives, therapeutic use Prednisone / therapeutic use Prospective Studies Retrospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 128794-94-5/mycophenolate mofetil; 24280-93-1/Mycophenolic Acid; 53-03-2/Prednisone; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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