Document Detail


Satisfactory outcome despite low 2-hour postdose cyclosporine level in Iranian kidney recipients.
MedLine Citation:
PMID:  19377217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Cyclosporine has a narrow therapeutic serum level in kidney transplantation. Achieving the recommended therapeutic levels is necessary, but in different ethnic groups, the impact of the cyclosporine level on patient and graft survival has not been fully addressed yet. We investigated this issue by studying the 2-hour postdose serum concentration of cyclosporine (C2) and the long-term graft and patient survival in Iranian transplant recipients.
MATERIALS AND METHODS: A total of 397 kidney recipients were evaluated for the C2 serum levels. All patients were under treatment with prednisolone, mycophenolate mofetil, and cyclosporine (Neoral). Measurements C2 were considered at different time intervals: the first 2 months, 2 to 6 months, and after 6 months posttransplantation. The mean of C2 levels at specified intervals were evaluated and compared with the recommended optimal ranges. Patient and graft survival rate were also calculated.
RESULTS: In the studied patients, C2 levels were lower than the upper recommended range in 96.9%, 83.6% and 64.5% in the first 2 months, between 2 and 6 months, and after 6 months posttransplantation, respectively. The overall 5-year patient and graft survival rates were 95% and 85%, respectively.
CONCLUSIONS: Despite the fact that the majority of the patients had C2 levels lower than the recommended values, we observed good patient and graft survival rates. Our data suggests that different populations may need different target levels definition.
Authors:
Vahid Pourfarziani; Eqlim Nemati; Saeed Taheri; Hamid Reza Khoddami-Vishte; Mehdi Azizabadi Farahani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Iranian journal of kidney diseases     Volume:  2     ISSN:  1735-8582     ISO Abbreviation:  Iran J Kidney Dis     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-06-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101316967     Medline TA:  Iran J Kidney Dis     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Affiliation:
Kidney Transplant Department, Baqiyatallah University of Medical Sciences, Tehran, Iran. cru.common@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Cyclosporine / administration & dosage*
Dose-Response Relationship, Drug
Drug Monitoring
Drug Therapy, Combination
Female
Graft Survival*
Humans
Immunosuppressive Agents / administration & dosage*
Kidney Transplantation*
Male
Middle Aged
Mycophenolic Acid / analogs & derivatives,  therapeutic use
Prednisone / therapeutic use
Prospective Studies
Retrospective Studies
Young Adult
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 53-03-2/Prednisone; 59865-13-3/Cyclosporine; 9242ECW6R0/mycophenolate mofetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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