Document Detail

Satiety and hunger induced by small and large duodenal loads of isotonic glucose.
MedLine Citation:
PMID:  1211447     Owner:  NLM     Status:  MEDLINE    
Hepatic-portal infusions of small or large flucose loads in the rabbit had little or no stimulating effect on postinfusion food intake. However, marked differential changes in appetite were observed when small and large glucose loads were infused into the duodenum. The satiating effect of small glucose loads contrasted sharply with an unusually high increase in food intake triggered by the infusions of larger amounts of glucose into the duodenum. The results are interpreted in terms of a possible involvement of the enteroinsular mechanism in the regulation of food intake. This mechanism is bypassed and its influence on food intake eliminated when glucose is infused directly into the portal circulation. The positive relationship between large amounts of alimentary carbohydrates and overeating is seen as a factor that may actively promote the development of obesity and diabetes mellitus.
M Rezek; V Havlicek; D Novin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  229     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-03-11     Completed Date:  1976-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  545-8     Citation Subset:  IM; S    
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MeSH Terms
Duodenum / physiology*
Glucose / administration & dosage*
Hunger / physiology*
Isotonic Solutions
Portal System / physiology
Satiation / physiology*
Satiety Response / physiology*
Sodium Chloride / administration & dosage,  pharmacology
Reg. No./Substance:
0/Isotonic Solutions; 50-99-7/Glucose; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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