Document Detail


Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage.
MedLine Citation:
PMID:  22833472     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Following their discovery in 1961, it was speculated that satellite cells were dormant myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this accumulated over the years, until the link between satellite cells and the myoblasts that appear during muscle regeneration was finally established. Subsequently, it was demonstrated that, when grafted, satellite cells could also self-renew, conferring on them the coveted status of 'stem cell'. The emergence of other cell types with myogenic potential, however, questioned the precise role of satellite cells. Here, we review recent recombination-based studies that have furthered our understanding of satellite cell biology. The clear consensus is that skeletal muscle does not regenerate without satellite cells, confirming their pivotal and non-redundant role.
Authors:
Frederic Relaix; Peter S Zammit
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2845-56     Citation Subset:  IM    
Affiliation:
UPMC Paris 06, UMR-S 787, F-75013, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vascular instruction of pancreas development.
Next Document:  The patient's use of metaphor within a palliative care setting: Theory, function and efficacy. A nar...