| Sargaquinoic acid and sargahydroquinoic acid from Sargassum yezoense stimulate adipocyte differentiation through PPARalpha/gamma activation in 3T3-L1 cells. | |
| | |
MedLine Citation:
|
PMID: 18804110 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We screened active compounds from natural marine products able to increase PPARalpha/gamma transcriptional activity. Sargaquinoic acid (SQA) and sargahydroquinoic acid (SHQA) from Sargassum yezoense were identified as novel PPARalpha/gamma dual agonists. The binding affinity of SQA with PPARgamma was higher than that of the specific PPARgamma agonist troglitazone, leading to an activation of PPARgamma transcriptional activity. In parallel, treatment of 3T3-L1 cells with SQA and SHQA led to an increase in adipocyte differentiation and increased expression of adipogenic marker genes such as aP2, PPARgamma, resistin, adiponectin, C/EBPalpha and Glut4. Collectively, our data suggest that SQA and SHQA are novel PPARalpha/gamma dual agonists and may be beneficial for reducing insulin resistance through regulation of adipogenesis. |
| | |
Authors:
|
Su-Nam Kim; Hye Young Choi; Woojung Lee; Gab Man Park; Woon Seob Shin; Yong Kee Kim |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-17 |
Journal Detail:
|
Title: FEBS letters Volume: 582 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-11-03 Completed Date: 2008-12-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 3465-72 Citation Subset: IM |
Affiliation:
|
KIST Gangneung Institute, Gangneung 210-340, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3T3-L1 Cells Adipocytes / cytology, drug effects*, metabolism Adipogenesis / drug effects*, genetics Alkenes / isolation & purification, pharmacology* Animals Benzoquinones / isolation & purification, pharmacology* Mice PPAR alpha / agonists*, metabolism PPAR gamma / agonists*, metabolism Sargassum / chemistry Transcription, Genetic / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Alkenes; 0/Benzoquinones; 0/PPAR alpha; 0/PPAR gamma; 0/sargahydroquinoic acid; 0/sargaquinoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mapping of yeast Rpn4p transactivation domains.
Next Document: Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic p...