Document Detail

Sarcopenia negatively affects preoperative total functional liver volume in patients undergoing liver resection.
MedLine Citation:
PMID:  23020663     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Sarcopenia may negatively affect short-term outcomes after liver resection. The present study aimed to explore whether total functional liver volume (TFLV) is related to sarcopenia in patients undergoing partial liver resection.
METHODS: Analysis of total liver volume and tumour volume and measurements of muscle surface were performed in patients undergoing liver resection using OsiriX(®) and preoperative computed tomography. The ratio of TFLV to bodyweight was calculated as: [TFLV (ml)/bodyweight (g)]*100%. The L3 muscle index (cm(2) /m(2) ) was then calculated by normalizing muscle areas (at the third lumbar vertebral level) for height.
RESULTS: Of 40 patients, 27 (67.5%) were classified as sarcopenic. There was a significant correlation between the L3 skeletal muscle index and TFLV (r= 0.64, P < 0.001). Median TFLV was significantly lower in the sarcopenia group than in the non-sarcopenia group [1396 ml (range: 1129-2625 ml) and 1840 ml (range: 867-2404 ml), respectively; P < 0.05]. Median TFLV : bodyweight ratio was significantly lower in the sarcopenia group than in the non-sarcopenia group [2.0% (range: 1.4-2.5%) and 2.3% (range: 1.5-2.5%), respectively; P < 0.05].
CONCLUSIONS: Sarcopenic patients had a disproportionally small preoperative TFLV compared with non-sarcopenic patients undergoing liver resection. The preoperative hepatic physiologic reserve may therefore be smaller in sarcopenic patients.
Simon A W G Dello; Toine M Lodewick; Ronald M van Dam; Kostan W Reisinger; Maartje A J van den Broek; Maarten F von Meyenfeldt; Marc H A Bemelmans; Steven W M Olde Damink; Cornelis H C Dejong
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Publication Detail:
Type:  Journal Article     Date:  2012-06-21
Journal Detail:
Title:  HPB : the official journal of the International Hepato Pancreato Biliary Association     Volume:  15     ISSN:  1477-2574     ISO Abbreviation:  HPB (Oxford)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-26     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  100900921     Medline TA:  HPB (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-9     Citation Subset:  IM    
Copyright Information:
© 2012 International Hepato-Pancreato-Biliary Association.
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MeSH Terms
Aged, 80 and over
Body Composition
Body Weight
Case-Control Studies
Linear Models
Liver / physiopathology,  radiography,  surgery*
Liver Neoplasms / complications,  physiopathology,  radiography,  surgery*
Middle Aged
Muscle, Skeletal / pathology*
Organ Size
Predictive Value of Tests
Risk Factors
Sarcopenia / complications*,  pathology,  physiopathology
Tomography, X-Ray Computed
Tumor Burden

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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