Document Detail


Sarcomere control mechanisms and the dynamics of the cardiac cycle.
MedLine Citation:
PMID:  20467475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review focuses on recent developments in the molecular mechanisms by which Ca activates cardiac sarcomeres and how these mechanisms play out in the cardiac cycle. I emphasize the role of mechanisms intrinsic to the sarcomeres as significant determinants of systolic elastance and ventricular stiffening during ejection. Data are presented supporting the idea that processes intrinsic to the thin filaments may promote cooperative activation of the sarcomeres and be an important factor in maintaining and modifying systolic elastance. Application of these ideas to translational medicine and rationale drug design forms an important rationale for detailed understanding of these processes.
Authors:
R John Solaro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-05-10
Journal Detail:
Title:  Journal of biomedicine & biotechnology     Volume:  2010     ISSN:  1110-7251     ISO Abbreviation:  J. Biomed. Biotechnol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-30     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101135740     Medline TA:  J Biomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105648     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Animals
Calcium / metabolism
Humans
Mice
Myocardial Contraction / physiology*
Myocytes, Cardiac / physiology*
Sarcomeres / physiology*
Troponin / metabolism
Grant Support
ID/Acronym/Agency:
P01 HL 62426/HL/NHLBI NIH HHS; R01 HL 22231/HL/NHLBI NIH HHS; R01 HL 64035/HL/NHLBI NIH HHS; R01 HL064035/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Actins; 0/Troponin; SY7Q814VUP/Calcium
Comments/Corrections

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