| Sarcomere control mechanisms and the dynamics of the cardiac cycle. | |
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MedLine Citation:
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PMID: 20467475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review focuses on recent developments in the molecular mechanisms by which Ca activates cardiac sarcomeres and how these mechanisms play out in the cardiac cycle. I emphasize the role of mechanisms intrinsic to the sarcomeres as significant determinants of systolic elastance and ventricular stiffening during ejection. Data are presented supporting the idea that processes intrinsic to the thin filaments may promote cooperative activation of the sarcomeres and be an important factor in maintaining and modifying systolic elastance. Application of these ideas to translational medicine and rationale drug design forms an important rationale for detailed understanding of these processes. |
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Authors:
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R John Solaro |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-05-10 |
Journal Detail:
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Title: Journal of biomedicine & biotechnology Volume: 2010 ISSN: 1110-7251 ISO Abbreviation: J. Biomed. Biotechnol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-08-30 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101135740 Medline TA: J Biomed Biotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 105648 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Ave, Chicago, IL 60612, USA. solarorj@uic.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Animals Calcium / metabolism Humans Mice Myocardial Contraction / physiology* Myocytes, Cardiac / physiology* Sarcomeres / physiology* Troponin / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL 62426/HL/NHLBI NIH HHS; R01 HL 22231/HL/NHLBI NIH HHS; R01 HL 64035/HL/NHLBI NIH HHS; R01 HL064035-12/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Troponin; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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