| Sarcoma arising as a distinct nodule within glioblastoma: a morphological and molecular perspective on gliosarcoma. | |
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MedLine Citation:
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PMID: 21533839 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Gliosarcoma is a variant of glioblastoma and is characterized by distinct glial and sarcomatous components. Typically, there is no macroscopic boundary between the components and special stains are often required to distinguish the glial and sarcomatous elements. Some studies suggest similar genetic alterations in both components pointing to a common origin. We present an extreme case of gliosarcoma arising as a discrete fibrous nodule adjacent to a typical glioblastoma. A 65 year-old woman presented with progressive weakness, seizures and right-sided hemiparesis. CT scan demonstrated an irregular enhancing left frontal lobe mass and an adjacent discrete nodule with different imaging characteristics. The unique nature of this macroscopically biphasic neoplasm allowed us to compare the molecular characteristics of glial and sarcomatous elements which were strikingly similar except for small losses and gains in Chr 3. Studies are under way to determine the significance of chromosome 3 alterations in gliosarcomas. |
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Authors:
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Cynthia Jimenez; Martin Powers; Andrew T Parsa; Christine Glastonbury; Jill M Hagenkord; Tarik Tihan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-1 |
Journal Detail:
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Title: Journal of neuro-oncology Volume: - ISSN: 1573-7373 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pathology, Neuropathology Unit, University of California at San Francisco, Room M551, 505 Parnassus Avenue, San Francisco, CA, 94143-0102, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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