Document Detail

Sarcoidosis: recurrence of primary disease in transplanted lungs.
MedLine Citation:
PMID:  8029415     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess findings of recurrent disease on thin-section computed tomographic (CT) studies and results of bronchoalveolar lavage and transbronchial biopsy (BAL-TBB) procedures performed in adult lung transplant recipients. MATERIALS AND METHODS: Between 1990 and 1993, 32 single-lung, 14 double-lung, and three heart-lung transplantation procedures were performed in 47 patients; 176 thin-section CT scans were reviewed, with a mean follow-up of 18.9 months after transplantation. RESULTS: Sarcoidosis was diagnosed after BAL-TBB of the lung allografts 3 and 15 months after transplantation in both patients without symptoms who received transplants for treatment of sarcoidosis. In one patient, diffuse miliary nodules seen on chest radiographs and thin-section CT scans disappeared after administration of an increased dose of corticosteroids; in the other patient, no radiologic finding of sarcoidosis was present. No recurrence was seen in patients who received transplants for treatment of other diseases. CONCLUSION: Recurrence of primary disease should be considered whenever abnormalities are seen on chest radiographs or thin-section CT scans. Sarcoidosis may recur with or without radiologic findings after transplantation.
E A Kazerooni; C Jackson; P N Cascade
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  192     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-08-11     Completed Date:  1994-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  461-4     Citation Subset:  AIM; IM    
Department of Radiology, University of Michigan Hospitals, Ann Arbor 48109-0326.
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MeSH Terms
Bronchoalveolar Lavage Fluid / cytology
Lung / pathology,  radiography
Lung Transplantation*
Middle Aged
Sarcoidosis, Pulmonary / diagnosis,  radiography,  surgery*
Tomography, X-Ray Computed

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