Document Detail

Sarcoidosis in a patient with AIDS: a manifestation of immune restoration syndrome.
MedLine Citation:
PMID:  10426909     Owner:  NLM     Status:  MEDLINE    
Sarcoidosis has been rarely reported in the presence of HIV infection. Helper T-lymphocyte depletion may attenuate granuloma formation. We present a patient who developed active sarcoidosis after being started on highly active antiretroviral therapy (HAART), which increased his CD4 count and decreased his viral load. There have been reports of exaggerated responses to mycobacteria and viruses with the restoration of T-cell function after HAART in HIV-infected patients. We propose that active sarcoidosis seen in this patient is also a manifestation of this newly observed "immune restoration disease."
P Mirmirani; T A Maurer; B Herndier; M McGrath; M D Weinstein; T G Berger
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  41     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-02     Completed Date:  1999-09-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-6     Citation Subset:  IM; X    
University of California, Department of Dermatology, San Francisco, CA 94143-0316, USA.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*,  drug therapy,  immunology,  virology
Acute Disease
Anti-HIV Agents / administration & dosage
CD4 Lymphocyte Count
Middle Aged
Sarcoidosis / complications*,  pathology
Skin / pathology
Viral Load
Grant Support
Reg. No./Substance:
0/Anti-HIV Agents

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