Document Detail

Sarcoidosis as a benign cause of lymphadenopathy in cancer patients.
MedLine Citation:
PMID:  19321155     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cancer and sarcoidosis have been associated in several small case series. This association makes the cancer patient with lymphadenopathy a diagnostic dilemma: malignant involvement of the lymph nodes is common, but benign diagnoses are possible and must be considered. METHODS: We conducted a retrospective chart review of all patients with a diagnosis of sarcoidosis or mediastinal adenopathy who underwent mediastinoscopy at the Swedish Medical Center and Cancer Institute from 2004 to 2008. RESULTS: Five hundred sixty-five mediastinoscopies were performed. There were 41 cases of biopsy-proven sarcoidosis. Twenty-one cases of sarcoidosis were diagnosed after a diagnosis of cancer. No primary cancer type was predominant. Cancers were of all stages, with and without lymph node involvement. The most common positron emission tomography combined with a computed tomography scan (PET CT) finding was bilateral hilar adenopathy with symmetric standardized uptake values (SUV) in the 4 to 15 range (62%), but many other PET CT patterns were present. CONCLUSIONS: Hypermetabolic lymphadenopathy on staging or surveillance imaging presents a diagnostic dilemma. Sarcoidosis must be considered in the differential diagnosis of patients with a history of malignancy who develop lymphadenopathy. It is imperative to obtain a tissue diagnosis before instituting therapy for presumed cancer recurrence.
Ben M Hunt; Eric Vallières; Gordon Buduhan; Ralph Aye; Brian Louie
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Publication Detail:
Type:  Journal Article     Date:  2009-03-24
Journal Detail:
Title:  American journal of surgery     Volume:  197     ISSN:  1879-1883     ISO Abbreviation:  Am. J. Surg.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-05-15     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629-32; discussion 632     Citation Subset:  AIM; IM    
Swedish Medical Center and Swedish Cancer Institute, Seattle, WA 98104-1306, USA.
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MeSH Terms
Breast Neoplasms / epidemiology*
Lung Neoplasms / epidemiology*
Lymphatic Diseases / epidemiology,  etiology*
Lymphoma, Non-Hodgkin / epidemiology*
Middle Aged
Positron-Emission Tomography
Retrospective Studies
Sarcoidosis / complications*,  epidemiology
Testicular Neoplasms / epidemiology*
Tomography, X-Ray Computed
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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