Document Detail

Sarcoidosis as an adverse effect of tumor necrosis factor inhibitors.
MedLine Citation:
PMID:  22527429     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tumor necrosis factor inhibitors are valuable tools for dermatologists. As their use increases, rare adverse events are more likely to be encountered.
OBJECTIVE: We describe one patient who developed sarcoidosis while being treated for psoriasis with etanercept. We sought to review to previously reported cases and further characterize the nature of this reaction.
METHODS: A literature search was performed with the key words "sarcoidosis, sarcoid, etanercept, infliximab, adalimumab, granulomatous, and drug reaction." All relevant cases in the English language were included and evaluated for demographic data, duration of therapy prior to developing sarcoid, duration of sarcoid signs/symptoms, treatments used and time to resolution after discontinuation of the drug.
RESULTS: Including the present case, there are 34 cases of sarcoidosis developing during anti-tumor necrosis factor therapy. All previously reported cases were patients with a primarily rheumatologic diagnosis. In all but one case, discontinuation of the drug resulted in complete resolution of symptoms. The lung and surrounding lymph nodes were the areas most commonly affected. The average amount of time between initiation of therapy and onset of symptoms was 22 months. The average time to resolution of symptoms after discontinuation of the drug was 5.2 months.
LIMITATIONS: This is a retrospective case review.
CONCLUSIONS: These data indicated that sarcoid is a possible adverse effect of tumor necrosis factor inhibitor therapy that should be noted by dermatologists using these drugs. While it has been reported in the rheumatology literature, it may be under-recognized by dermatologists.
Shelley Cathcart; Naveed Sami; Boni Elewski
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  11     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-08-15     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  609-12     Citation Subset:  IM    
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MeSH Terms
Immunoglobulin G / administration & dosage,  adverse effects,  therapeutic use
Immunologic Factors / administration & dosage,  adverse effects*,  therapeutic use
Middle Aged
Psoriasis / drug therapy
Receptors, Tumor Necrosis Factor / administration & dosage,  therapeutic use
Retrospective Studies
Sarcoidosis / chemically induced*
Time Factors
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunologic Factors; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 185243-69-0/TNFR-Fc fusion protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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