| Sarcoidosis following Cushing's syndrome: A report of two cases and review of the literature. | |
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MedLine Citation:
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PMID: 20162506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cushing's syndrome is characterized by excessive elevation of glucocorticoid concentrations. In rare cases, the treatment of Cushing's syndrome may result in unmasking or aggravation of diseases responsive to glucocorticoid medication. We report two cases of sarcoidosis following Cushing's syndrome. A 43 year-old male developed cutaneous sarcoidosis and mediastinal lymphadenopathy after resection of an ACTH-secreting pituitary microadenoma. A 32 year-old female showed cutaneous sarcoidosis, arthralgia, mediastinal lymphadenopathy and elevation of angiotensin-converting enzyme and interleukin 2-receptor concentrations after traumatic adrenal bleeding, which ceased formerly undiagnosed hypercortisolism caused by an adrenal adenoma. Sarcoidosis seems to be a rare sequel following the treatment of hypercortisolism. Skin affections were present and suggestive for the diagnosis in all reported cases. As some cases are probably missed when skin affections are lacking, a more frequent evaluation of patients after Cushing's syndrome for the possible diagnosis of sarcoidosis might be necessary. |
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Authors:
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S Schaefer; S Meyer; C C Brueck; M Weber; D Luedecke; H J Wagner; P H Kann |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2010-02-16 |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 118 ISSN: 1439-3646 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
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Languages: eng Pagination: 147-50 Citation Subset: IM |
Copyright Information:
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J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart * New York. |
Affiliation:
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Philipps University Marburg, Marburg. stscha@med.uni-marburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ACTH-Secreting Pituitary Adenoma
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surgery* Adenoma / surgery* Adult Arthralgia / diagnosis, etiology Cushing Syndrome / surgery* Female Humans Lymphatic Diseases / diagnosis, etiology Male Mediastinal Diseases / diagnosis, etiology Peptidyl-Dipeptidase A / analysis Receptors, Interleukin-2 / analysis Sarcoidosis / diagnosis, etiology* Skin Diseases / diagnosis, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Interleukin-2; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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