Document Detail

Sarcoid myopathy and mitochondrial respiratory chain defects: clinicopathological, biochemical and molecular biological analyses.
MedLine Citation:
PMID:  7580239     Owner:  NLM     Status:  MEDLINE    
We report on a 33-yr-old female patient with myalgia, CK values up to 3500 Ul-1 and proximal weakness. An initial muscle biopsy showed myositis. One year later an enlarged lymph node was investigated and sarcoidosis diagnosed. In a second muscle biopsy inflammatory cells and morphological characteristics of mitochondrial myopathy were found. Biochemical analyses indicated a 50% reduction in complex II activity of the respiratory chain. Due to failure in clinical improvement a third muscle biopsy was performed in 1990 where only 19% of normal complex II activity was present. Southern blot analysis of the mitochondrial genome was normal. Thus for the first time we describe a patient with sarcoid myopathy and a complex II deficiency. Our interpretation is that a pre-existing complex II defect became clinically relevant because of additional sarcoid myopathy.
H Reichmann; B Schalke; P Seibel; M Naumann; K Toyka
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuromuscular disorders : NMD     Volume:  5     ISSN:  0960-8966     ISO Abbreviation:  Neuromuscul. Disord.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-27     Completed Date:  1995-11-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111470     Medline TA:  Neuromuscul Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Department of Neurology, University of Würzburg, Germany.
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MeSH Terms
Blotting, Southern
DNA / analysis
Electron Transport / genetics*
Microscopy, Electron
Mitochondrial Myopathies / complications,  enzymology*,  genetics*
Muscle Fibers, Skeletal / enzymology
Muscle, Skeletal / enzymology,  pathology,  ultrastructure
Myositis / complications*,  genetics,  pathology
Sarcoidosis / complications*,  pathology
Succinate Cytochrome c Oxidoreductase / deficiency
Succinate Dehydrogenase / deficiency
Reg. No./Substance:
9007-49-2/DNA; EC 1.-/Succinate Cytochrome c Oxidoreductase; EC Dehydrogenase

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