Document Detail

Sarcoid-like granulomatosis in patients treated with anti-TNFα factors. A case report and review of the literature.
MedLine Citation:
PMID:  20972592     Owner:  NLM     Status:  MEDLINE    
This report describes a 56-year-old woman who developed granulomatous lesions consistent with sarcoidosis during adalimumab therapy for rheumatoid arthritis. Cervical and axillary lymphadenopathy developed approximately 21 months after adalimumab administration. Non-caseating epithelioid cell granulomas consistent with sarcoidosis were detected both in an axillary lymph node specimen and in the bone marrow. Diseases showing similar histologic changes, especially tuberculosis, were excluded, and a diagnosis of sarcoidosis was made. Adalimumab was discontinued, and recovery was observed. The current case is, to our knowledge, the first to describe adalimumab-induced non-caseating granulomas in lymph nodes and bone marrow without pulmonary involvement in a patient treated for rheumatoid arthritis.
Theoni Kanellopoulou; Anna Filiotou; Hariklia Kranidioti; Spyridon P Dourakis
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-10-23
Journal Detail:
Title:  Clinical rheumatology     Volume:  30     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-24     Completed Date:  2011-07-21     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  581-3     Citation Subset:  IM    
2nd Department of Internal Medicine, Medical School of Athens University, "Hippokration" General Hospital of Athens, Athens, Greece.
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MeSH Terms
Antibodies, Monoclonal / adverse effects*,  therapeutic use
Antibodies, Monoclonal, Humanized
Antirheumatic Agents / adverse effects*,  therapeutic use
Arthritis, Rheumatoid / drug therapy*
Bone Marrow / pathology
Granuloma / chemically induced*,  diagnosis
Lymph Nodes / pathology
Middle Aged
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antirheumatic Agents; FYS6T7F842/adalimumab

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