Document Detail


Sarcoglycan[s] are not muscle-specific: hypothetical roles.
MedLine Citation:
PMID:  21072985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sarcoglycan complex is a multimember transmembrane complex interacting with other proteins to provide a mechano-signaling connection from the cytoskeleton to the extracellular matrix in myofibers. This complex plays a key role at the membrane and is crucial in maintaining sarcolemma viability in muscle fibers. Recent observations have demonstrated that in the lung this glycoprotein is associated with both alveoli and bronchioles, and that the urogenital and digestive tracts are epsilon-sarcoglycan positive. Further addressing this issue, in this work we extend our previous studies to better verify whether the sarcoglycan complex also exists in epithelial tissue. All our observations showed staining for all sarcoglycans to be a normal pattern in all tested epithelial cells. We hypothesize a key role for sarcoglycans in bidirectional signaling between cells and extracellular matrix, and an important role in the regulation of inhibitory synapses and of blood brain barrier.
Authors:
Giuseppe Anastasi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia     Volume:  115     ISSN:  1122-6714     ISO Abbreviation:  Ital J Anat Embryol     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612303     Medline TA:  Ital J Anat Embryol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
Affiliation:
Department of Biomorphology and Biotechnologies, University of Messina. anapuc@unime.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood-Brain Barrier / chemistry,  physiology
Brain Chemistry / physiology
Cell Communication / physiology
Cytoskeleton / chemistry,  physiology
Epithelial Cells / chemistry,  cytology,  metabolism*
Extracellular Matrix / chemistry,  physiology
Humans
Male
Middle Aged
Muscle Proteins / chemistry,  metabolism
Organ Specificity / physiology
Protein Isoforms / chemistry,  physiology
Sarcoglycans / chemistry*,  physiology*
Signal Transduction / physiology
Viscera / chemistry,  cytology,  metabolism
Chemical
Reg. No./Substance:
0/Muscle Proteins; 0/Protein Isoforms; 0/Sarcoglycans

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