Document Detail


Sarcina organisms in the gastrointestinal tract: a clinicopathologic and molecular study.
MedLine Citation:
PMID:  21997690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sarcina organisms were first observed in and recorded from the stomach contents of a patient suffering from vomiting by John Goodsir in 1842. Since that time, their fine structure, phylogenetic classification, and biochemical characteristics have been described. Although numerous cases of fatal disease have been attributed to this organism in the veterinary literature, only a few human cases have been documented. As a result, whether this organism causes disease in humans has not been definitively established. We report the clinicopathologic findings in a series of 5 patients with Sarcina-like organisms identified in upper gastrointestinal endoscopic biopsies with molecular confirmation. Our findings have shown that the organism is most commonly found in patients with a history of gastric outlet obstruction or delayed gastric emptying. Although many of the patients do not demonstrate direct mucosal injury from the organism, the presence of a concurrent gastric ulcer puts the patient at increased risk for complications such as emphysematous gastritis or perforation. The finding of Sarcina organisms should prompt further investigation for functional causes of gastric outlet obstruction and delayed gastric emptying, such as occult malignancy.
Authors:
Dora Lam-Himlin; Athanasios C Tsiatis; Elizabeth Montgomery; Rish K Pai; J Ahmad Brown; Mohammad Razavi; Laura Lamps; James R Eshleman; Belur Bhagavan; Robert A Anders
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  35     ISSN:  1532-0979     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-14     Completed Date:  2011-12-07     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1700-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Baltimore
Biopsy
Child
DNA, Bacterial / analysis
Endoscopy, Gastrointestinal
Female
Gastric Outlet Obstruction / complications
Gastroparesis / complications
Gram-Positive Bacterial Infections / microbiology*,  pathology
Humans
Male
Middle Aged
Polymerase Chain Reaction
Prospective Studies
RNA, Ribosomal, 16S / analysis
Ribotyping
Risk Factors
Sarcina / classification,  genetics,  isolation & purification*
Stomach / microbiology*,  pathology
Stomach Ulcer / complications
Grant Support
ID/Acronym/Agency:
R01 DK080736/DK/NIDDK NIH HHS; R01 DK080736-01A2/DK/NIDDK NIH HHS; R01 DK081417/DK/NIDDK NIH HHS; R01 DK081417-01/DK/NIDDK NIH HHS; R01 DK081417-02/DK/NIDDK NIH HHS; R01 DK081417-03/DK/NIDDK NIH HHS; R01DK080736/DK/NIDDK NIH HHS; R01DK081417/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/RNA, Ribosomal, 16S
Comments/Corrections

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