Document Detail


Saponins in garlic as modifiers of the risk of cardiovascular disease.
MedLine Citation:
PMID:  11238805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most chemical and biological studies about garlic have been conducted using organosulfur compounds. However, a variety of steroid saponins from garlic and related Allium species are being increasingly recognized for their importance in biological processes. This report demonstrates the isolation and structure determination of steroid saponins from garlic and aged garlic extract (AGE). In addition, the in vitro antifungal antitumor cytotoxicity and blood coagulability effects of steroid saponins from garlic and related Allium species are provided. Animal studies on the cholesterol-lowering effects of the saponin fractions from garlic are also summarized.
Authors:
H Matsuura
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  131     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-04-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1000S-5S     Citation Subset:  IM    
Affiliation:
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticarcinogenic Agents / isolation & purification,  therapeutic use
Anticholesteremic Agents / isolation & purification,  therapeutic use*
Antifungal Agents / isolation & purification,  therapeutic use
Cardiovascular Diseases / drug therapy,  prevention & control*
Garlic / chemistry*
Humans
Magnetic Resonance Spectroscopy
Plant Extracts / chemistry
Plants, Medicinal*
Rats
Risk Factors
Saponins / chemistry,  isolation & purification*,  pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Anticholesteremic Agents; 0/Antifungal Agents; 0/Plant Extracts; 0/Saponins

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