| Saponins from Plumeria acuminata Ait induce cell growth inhibition and apoptosis of oral squamous carcinoma cells. | |
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MedLine Citation:
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PMID: 21264367 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: to investigate the cytotoxic and apoptotic effects of saponins from Plumeria acuminata Ait on oral squamous carcinoma cells (OSCC). METHODS: OSCC cells seeded at 2 × 104 cells/well in a 96-well plate were treated with saponins from P. acuminata Ait and cisplatin in various concentrations for 24 h. Trypan blue dye exclusion assay and ethidium bromide/acridine orange were used to evaluate their cytotoxic and apoptotic effects on the cells, respectively. RESULTS: the results showed that both saponins and cisplatin had cytotoxic and apoptotic effects on OSCC cells. CONCLUSION: saponins from P. acuminata Ait may be potential anti-cancer agents for OSCC. |
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Authors:
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Hendri Susanto; Nanang Fakhrudin; Yosi Bayu Murti; Supriatno; Widowati Siswomiharjo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Volume: 13 ISSN: 1462-6446 ISO Abbreviation: Chin J Dent Res Publication Date: 2010 |
Date Detail:
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Created Date: 2011-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892845 Medline TA: Chin J Dent Res Country: England |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: D; IM |
Affiliation:
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Oral Medical Department, Faculty of Dentistry, University of Gadjah Mada, Yogyakarta, Indonesia. drghendri@ugm.ac.id |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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