| Sanggenon C decreases tumor cell viability associated with proteasome inhibition. | |
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MedLine Citation:
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PMID: 21622138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several flavonoids have been reported to be proteasome inhibitors, but whether prenylated flavonoids are able to inhibit proteasome function remains unknown. We report for the first time that Sanggenon C, a natural prenylated flavonoid, inhibits tumor cellular proteasomal activity and cell viability. We found that (1) Sanggenon C inhibited tumor cell viability and induced cell cycle arrest at G0/G1 phase; (2) Sanggenon C inhibited the chymotrypsin-like activity of purified human 20S proteasome and 26S proteasome in H22 cell lysate, and Sanggenon C was able to dose-dependently accumulate ubiquitinated proteins and proteasome substrate protein p27; (3) Sanggenon C-induced proteasome inhibition occurred prior to cell death in murine H22 and P388 cell lines; (4) Sanggenon C induced death of human K562 cancer cells and primary cells isolated from leukemic patients. We conclude that Sanggenon C inhibits tumor cell viability via induction of cell cycle arrest and cell death, which is associated with its ability to inhibit the proteasome function and that proteasome inhibition by Sanggenon C at least partially contributes to the observed tumor cell growth-inhibitory activity. |
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Authors:
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Hongbiao Huang; Ningning Liu; Kai Zhao; Chenchen Zhu; Xiaoyu Lu; Shujue Li; Wen Lian; Ping Zhou; Xiaoxian Dong; Canguo Zhao; Haiping Guo; Change Zhang; Changshan Yang; Guanmei Wen; Li Lu; Xiaofen Li; Lixia Guan; Chunjiao Liu; Xuejun Wang; Qing Ping Dou; Jinbao Liu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-06-01 |
Journal Detail:
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Title: Frontiers in bioscience (Elite edition) Volume: 3 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-30 Completed Date: 2011-10-10 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 1315-25 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzofurans / pharmacology* Blotting, Western Cell Cycle / drug effects Cell Line, Tumor Cell Survival / drug effects Chromones / pharmacology* Mice |
| Grant Support | |
ID/Acronym/Agency:
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1R01CA120009/CA/NCI NIH HHS; 3R01CA120009-04S1/CA/NCI NIH HHS; R01 CA120009-04/CA/NCI NIH HHS; R01 CA120009-04S1/CA/NCI NIH HHS; R01 CA120009-05/CA/NCI NIH HHS; R01 HL072166-07/HL/NHLBI NIH HHS; R01 HL072166-08/HL/NHLBI NIH HHS; R01 HL072166-09/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/Chromones; 80651-76-9/sanggenone C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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