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Sampling variability of transient elastography according to probe location.
MedLine Citation:
PMID:  21537125     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND AIMS: Heterogeneity of fibrosis throughout the liver has been reported. However, the need for several measurements when using transient elastography was not thoroughly investigated. The aim was to find out whether measurement of liver stiffness varies according to the probe location.
METHODS: Six hundred and twenty-five consecutive patients with chronic liver diseases referred for transient elastography were enrolled. All patients underwent successive liver stiffness measurements at three different sites. Representative measurements were acquisitions with a success rate greater than 60% and an interquartile range lower than 30% of the median.
RESULTS: The sample included 371 eligible patients with three representative measurements. Comparing the three successive measurements categorized to fibrosis stages F0-F4, 68.2% of patients had agreement between all three sites. Discordance of one stage was noted in 28.3% of the patients, in 7% for two stages, and in 1.4% for three stages.The κ for comparing the maximal versus the minimal results was 0.43. There was no significant difference in the characteristics of patients with discordance and patients without discordance including age, sex, waist circumference, BMI, and etiology of liver disease. The stage of fibrosis was associated with discordance between measurements (P<0.001), demonstrating low discordance rate in patients with stages F0-F1 or F4 and high discordance rate in patients with stages F2 and F3.
CONCLUSION: Sampling variability according to probe location is seen in transient elastography in approximately 30% of patients. Therefore, it may be suggested to perform transient elastography from various sites to minimize the sample error.
Shira Zelber-Sagi; Hanny Yeshua; Amir Shlomai; Laurie Blendis; Moshe Leshno; Stella Levit; Zamir Halpern; Ran Oren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  23     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  507-14     Citation Subset:  IM    
aDepartment of Gastroenterology and Liver, Tel Aviv Sourasky Medical Center bSchool of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa cDepartment of Family Medicine, Clalit Health Services, Tel-Aviv dSackler Faculty of Medicine, Tel-Aviv University, Israel.
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