| Sampling time, dosage schedule, and nortriptyline plasma levels. | |
| | |
MedLine Citation:
|
PMID: 871235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Steady-state nortriptyline plasma levels were determined in eight patients at 9 AM, 12 PM, 3 PM, and 6 PM during treatment with nortriptyline hydrochloride administered as a single daily bedtime (hs) dose at 10 PM and repeated after changing the dosage schedule to three times a day (tid) with divided doses at 10 AM, 4 PM, and 10 PM. Overall, the mean levels were stable during the sampling period and comparable on the two schedules. As expected, the plasma level decreased at the later sampling times on the hs schedule and increased on the tid schedule. In seven of the eight patients, the differences on the two dosage schedules were less than 30 ng/ml, which is not considered clinically significant. One patient had a higher plasma nortriptyline level on the tid schedule, which was clinically significant. Standardization of sampling time is of importance when comparing plasma levels and therapeutic response in treatment studies. |
| | |
Authors:
|
V E Ziegler; J W Knesevich; L T Wylie; J T Biggs |
Related Documents
:
|
10425465 - Plasma oestrogen fractions in postmenopausal women receiving hormone replacement therap... 7330795 - Serum, saliva, and sputum levels of metronidazole in acute exacerbations of chronic bro... 9675 - Time course of free and n4-acetylated sulfapyridine concentrations in the plasma and sa... 447435 - The pharmacokinetics of dapsone and acetylated dapsone in serum and saliva. 21511405 - Changes in faecal bacteria and metabolic parameters in foals during the first six weeks... 7146905 - Ban of ddt and subsequent recovery of reproduction in bald eagles. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Archives of general psychiatry Volume: 34 ISSN: 0003-990X ISO Abbreviation: Arch. Gen. Psychiatry Publication Date: 1977 May |
Date Detail:
|
Created Date: 1977-06-30 Completed Date: 1977-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 613-5 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Depression
/
drug therapy* Drug Administration Schedule Humans Nortriptyline / administration & dosage, blood*, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
|
72-69-5/Nortriptyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reduced MAO activity in first-degree relatives of individuals with bipolar affective disorders. A pr...
Next Document: Exercise stress test interpretation for cardiac diagnosis and functional evaluation.