Document Detail


Sampling of cardiovascular data; how often and how much?
MedLine Citation:
PMID:  18525015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term measurement of cardiovascular variables by telemetry in laboratory animals has become indispensable in recent years. However, limited battery life and management of large volumes of recorded data are major drawbacks. These limitations can often be overcome by intermittent sampling of data. The question is, how much data does one need to collect to accurately reflect the underlying average value? To investigate this, 24-h continuous recordings of rabbit heart rate, arterial pressure, and integrated renal sympathetic nerve activity (RSNA) were resampled using a variety of protocols that differed with respect to the number of individual sampling periods used and the total amount of time that was sampled. The absolute percentage errors of estimates of the daily mean, standard deviation, and interquartile range were calculated for each sampling protocol. A similar analysis was repeated using arterial pressure data from rats. The results show that the number of sampling periods spread throughout the day had more effect than the total amount of data recorded. For example, just 2 h of total sampling time spread over 12 evenly spaced 10-min periods gave estimates of the daily mean of blood pressure and heart rate with <1% error and RSNA with <3% error. We show that accurate estimates of the daily mean of arterial pressure, heart rate, and RSNA can all be made using scheduled recording, and we recommend recording a minimum of 2 h/day spread over a number of periods throughout the day.
Authors:
Sarah-Jane Guild; Carolyn J Barrett; Fiona D McBryde; Bruce N Van Vliet; Simon C Malpas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-04
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  295     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R510-5     Citation Subset:  IM    
Affiliation:
Circulatory Control Laboratory, Department of Physiology and Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand. s.guild@auckland.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory / methods*
Data Collection
Electrocardiography, Ambulatory / methods*
Heart Rate / physiology*
Kidney / innervation*
Rabbits
Reproducibility of Results
Research Design*
Sympathetic Nervous System / physiology*
Telemetry*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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