| Sampling of CSF via the Cisterna Magna and Blood Collection via the Heart Affects Brain Water Content in a Rat SAH Model. | |
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MedLine Citation:
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PMID: 21666823 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study was to evaluate whether sampling of cerebrospinal fluid (CSF) via the cisterna magna and of blood via the heart affects brain water content in a rat subarachnoid hemorrhage (SAH) model. Twenty-nine animals were divided into four groups: sham-operated group with sampling of CSF and blood (Sham S+), sham-operated group without sampling of CSF and blood (Sham S-), SAH group with sampling of CSF and blood (SAH S+), and SAH without sampling of CSF and blood (SAH S-). SAH was induced via endovascular perforation of the left internal carotid artery bifurcation. Cerebrospinal fluid via the cisterna magna and blood via cardiac puncture was collected in the Sham S+ and SAH S+ groups before killing the animals for brain water content measurements. Left hemisphere brain water content was significantly higher in the SAH S- group compared with the Sham S- group (p< 0.05) and in Sham S+ group compared with the Sham S- group (p<0.05). There was no significant difference in brain water content of the left hemisphere between the SAH S+ and Sham S+ groups (p=NS). There was no significant difference in brain water content in other parts of brains. Sampling of CSF and blood affected brain water content in Sham animals and therefore it is not accurate to use these values from Sham animals for comparison with SAH animals. |
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Authors:
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Kamil Duris; Anatol Manaenko; Hidenori Suzuki; William Rolland; Jiping Tang; John H Zhang |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Translational stroke research Volume: 2 ISSN: 1868-601X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101517297 Medline TA: Transl Stroke Res Country: - |
Other Details:
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Languages: ENG Pagination: 232-237 Citation Subset: - |
Affiliation:
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Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 NS053407-05//NINDS NIH HHS |
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