Document Detail


Sample size for a dose-response study.
MedLine Citation:
PMID:  1300202     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper deals with a method of sample size allocation for a dose-response study assuming a logistic model for the dose-response curve. The method is based on the precision with which one wishes to estimate the dose that would produce the efficacy resulting in a clinically important difference from a placebo. An example is given to illustrate the methodology. The main development of the paper is for a binary response and is suitably modified for a continuous variable.
Authors:
H I Patel
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of biopharmaceutical statistics     Volume:  2     ISSN:  1054-3406     ISO Abbreviation:  J Biopharm Stat     Publication Date:  1992  
Date Detail:
Created Date:  1993-05-26     Completed Date:  1993-05-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9200436     Medline TA:  J Biopharm Stat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Berlex Laboratories, Inc., Wayne, New Jersey 07470.
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MeSH Terms
Descriptor/Qualifier:
Dose-Response Relationship, Drug*
Humans
Models, Statistical*
Research Design / statistics & numerical data*
Comments/Corrections
Erratum In:
J Biopharm Stat 1994 Mar;4(1):127

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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