Document Detail

Same efficacies of ipratropium and salbutamol in reversing methacholine-induced bronchoconstriction.
MedLine Citation:
PMID:  17092849     Owner:  NLM     Status:  MEDLINE    
Efficacy of salbutamol (S) was compared to that of ipratropium (I) or to their association, after methacholine challenge testing (MCT). MCT was performed in 4 groups of 10 patients suspected to suffer from asthma; mean changes in FEV1, maximal midexpiratory flow rate (MMFR), and airway resistance (Raw) were the same in all groups. After MCT, the group 1 patients inhaled S and then I, 10 min later; both drugs were given in the reverse order to the group 2 patients. The group 3 patients inhaled a mixture of both drugs just after MCT; the group 4 patients were not given any bronchodilator till the 20th min after MCT, when they inhaled S. Short-term (10 min) bronchodilator effects of S, I or S + I on spirometric variables were of the same magnitude and Raw returned to its baseline value. Further improvement (10-20 min) in FEV1 was mainly due to spontaneous recovery, whereas further increase in MMFR was due also to bronchodilator actions of drugs. It is concluded that ipratropium could be proposed as an alternative bronchodilator to salbutamol after MCT.
S Delpierre; C Guillot; M Badier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  43     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-09     Completed Date:  2007-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  679-85     Citation Subset:  IM    
Laboratoire d'Explorations Fonctionnelles Respiratoires, Marseille, France.
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MeSH Terms
Airway Resistance / drug effects
Albuterol / therapeutic use*
Bronchial Provocation Tests*
Bronchoconstriction / drug effects*
Bronchoconstrictor Agents / diagnostic use*
Bronchodilator Agents / therapeutic use*
Forced Expiratory Volume / drug effects
Ipratropium / therapeutic use*
Maximal Midexpiratory Flow Rate / drug effects
Methacholine Chloride / diagnostic use*
Vital Capacity / drug effects
Reg. No./Substance:
0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 18559-94-9/Albuterol; 60205-81-4/Ipratropium; 62-51-1/Methacholine Chloride

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