| Same efficacies of ipratropium and salbutamol in reversing methacholine-induced bronchoconstriction. | |
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MedLine Citation:
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PMID: 17092849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Efficacy of salbutamol (S) was compared to that of ipratropium (I) or to their association, after methacholine challenge testing (MCT). MCT was performed in 4 groups of 10 patients suspected to suffer from asthma; mean changes in FEV1, maximal midexpiratory flow rate (MMFR), and airway resistance (Raw) were the same in all groups. After MCT, the group 1 patients inhaled S and then I, 10 min later; both drugs were given in the reverse order to the group 2 patients. The group 3 patients inhaled a mixture of both drugs just after MCT; the group 4 patients were not given any bronchodilator till the 20th min after MCT, when they inhaled S. Short-term (10 min) bronchodilator effects of S, I or S + I on spirometric variables were of the same magnitude and Raw returned to its baseline value. Further improvement (10-20 min) in FEV1 was mainly due to spontaneous recovery, whereas further increase in MMFR was due also to bronchodilator actions of drugs. It is concluded that ipratropium could be proposed as an alternative bronchodilator to salbutamol after MCT. |
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Authors:
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S Delpierre; C Guillot; M Badier |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 43 ISSN: 0277-0903 ISO Abbreviation: J Asthma Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-09 Completed Date: 2007-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: United States |
Other Details:
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Languages: eng Pagination: 679-85 Citation Subset: IM |
Affiliation:
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Laboratoire d'Explorations Fonctionnelles Respiratoires, Marseille, France. stephane-jean.delpierre@ap-hm.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Resistance / drug effects Albuterol / therapeutic use* Bronchial Provocation Tests* Bronchoconstriction / drug effects* Bronchoconstrictor Agents / diagnostic use* Bronchodilator Agents / therapeutic use* Female Forced Expiratory Volume / drug effects Humans Ipratropium / therapeutic use* Male Maximal Midexpiratory Flow Rate / drug effects Methacholine Chloride / diagnostic use* Vital Capacity / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 18559-94-9/Albuterol; 60205-81-4/Ipratropium; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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