Document Detail

Same effect of sublingual and oral captopril in hypertensive crisis.
MedLine Citation:
PMID:  23161035     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Hypertensive crisis is a condition characterized by rapid and inappropriate symptomatic elevation of blood pressure (BP) that is commonly seen in Emergency Departments. Oral or sublingual captopril is commonly used in the Emergency Departments. The unpleasant taste of the sublingual drugs causes uncomfortable condition to the patient. Studies showing no difference between oral and sublingual captopril has been ignored so far. Herein we compared the oral and sublingual captopril efficiency in the hypertensive urgencies.
MATERIALS AND METHODS: In this retrospective observational study, 71 patients admitted with hypertensive urgency to Emergency Departments of two hospitals in 2011 whose blood pressure were recorded before captopril administration and blood pressure were recorded after captopril administration at 0-5-15-30-45-60 minutes were included the study. The reductions of the blood pressure of oral and sublingual captopril groups were compared.
RESULTS: There were 28 patients at oral and 43 at sublingual captopril group. The mean age ± SD was 58.13 ± 8.66 years and 41 (57.7%) patients were female. The most common complaints were headache, nausea/vomiting and weakness. 65 (91.5%) patients were using antihypertensive drugs before admitted to hospital. The blood pressure at 0, 5, 15, 30, 45 and 60th minutes of therapy didn't show any difference between oral and sublingual captopril use.
CONCLUSIONS: There was any difference between oral and sublingual captopril efficiency to control of hypertension in patient with hypertensive urgency. For a more comfortable treatment, oral captopril may be a more convenient choice in the hypertensive urgencies.
E Karakiliç; F Büyükcam; G Kocalar; S Gedik; E Atalar
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European review for medical and pharmacological sciences     Volume:  16     ISSN:  1128-3602     ISO Abbreviation:  Eur Rev Med Pharmacol Sci     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2013-01-22     Revised Date:  2013-01-29    
Medline Journal Info:
Nlm Unique ID:  9717360     Medline TA:  Eur Rev Med Pharmacol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1642-5     Citation Subset:  IM    
Department of Emergency Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
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MeSH Terms
Administration, Oral
Administration, Sublingual
Antihypertensive Agents / administration & dosage,  adverse effects,  pharmacology,  therapeutic use*
Blood Pressure / drug effects
Captopril / administration & dosage*,  adverse effects,  pharmacology,  therapeutic use*
Hypertension / drug therapy*
Middle Aged
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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