Document Detail

Samarium Sm-153 lexidronam for the palliation of bone pain associated with metastases.
MedLine Citation:
PMID:  10898337     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In patients with bone pain due to metastatic disease, intravenous systemic radioisotope therapy may be a useful adjunct to other methods for palliating pain. METHODS: Various studies have been performed utilizing a short-lived radioisotope conjugated to a tetraphosphonate (samarium 153 lexidronam) both as an open label and as a double blinded, placebo-controlled study. Patients with varying tumor types including those of the prostate, breast, lung, and other sites were studied. Two dose levels were used (0.5 millicuries (mCi)/kg and 1.0 mCi/kg) with patients monitored for 16 weeks for efficacy (pain scores, opiod analgesic score, and quality of life) parameters and adverse events. RESULTS: All 3 studies showed that at the 1.0 mCi/kg dose level statistically significant improvement over placebo was observed by 4 weeks with relief of pain noted in many patients by 1 week. The only significant adverse event was transient myelosuppression with a nadir at 4-6 weeks and recovery by 8 weeks. Less than 10% of patients had National Cancer Institute Common Toxicity Criteria Grade III/IV bone marrow toxicity recorded. CONCLUSIONS: Systemic metabolic radiotherapy with samarium 153 lexidronam appears to be a safe and efficacious method for treating patients with bone pain. The shorter radioisotope half-life allows for a high dose rate to be delivered over a short period, which may have certain biologic benefits.
A N Serafini
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Review    
Journal Detail:
Title:  Cancer     Volume:  88     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-27     Completed Date:  2000-07-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2934-9     Citation Subset:  AIM; IM    
Department of Radiology and Medicine, University of Miami School of Medicine, Florida 33136, USA.
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MeSH Terms
Bone Neoplasms / physiopathology,  radiotherapy*,  secondary*
Clinical Trials as Topic
Pain / therapy*
Palliative Care*
Samarium / adverse effects,  pharmacokinetics,  therapeutic use*
Reg. No./Substance:

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