| Salvianolic acid A protects against vascular endothelial dysfunction in high-fat diet fed and streptozotocin-induced diabetic rats. | |
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MedLine Citation:
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PMID: 21972802 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Salvianolic acid A (SalA) is one of the main active ingredients of Salvia miltiorrhizae. The objective of this study was to evaluate the effect of SalA on the diabetic vascular endothelial dysfunction (VED). The rats were given a high-fat and high-sucrose diet for 1 month followed by intraperitoneal injection of streptozotocin (30 mg/kg). The diabetic rats were treated with SalA (1 mg/kg, 90% purity) orally for 10 weeks after modeling, and were given a high-fat diet. Contractile and relaxant responses of aorta rings as well as the serum indications were measured. Our results indicated that SalA treatment decreased the level of serum Von Willebrand factor and ameliorated acetylcholine-induced relaxation and KCl-induced contraction in aorta rings of the diabetic rats. SalA treatment also reduced the serum malondialdehyde, the content of aortic advanced glycation end products (AGEs), and the nitric oxide synthase (NOS) activity as well as the expression of endothelial NOS protein in the rat aorta. Exposure of EA.hy926 cells to AGEs decreased the cell viability and changed the cell morphology, whereas SalA had protective effect on AGEs-induced cellular vitality. Our data suggested that SalA could protect against vascular VED in diabetes, which might attribute to its suppressive effect on oxidative stress and AGEs-induced endothelial dysfunction. |
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Authors:
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Xiu-Ying Yang; Gui-Fen Qiang; Li Zhang; Xiao-Ming Zhu; Shou-Bao Wang; Lan Sun; Hai-Guang Yang; Guan-Hua Du |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Asian natural products research Volume: 13 ISSN: 1477-2213 ISO Abbreviation: J Asian Nat Prod Res Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888334 Medline TA: J Asian Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 884-94 Citation Subset: IM |
Affiliation:
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a Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 100050 , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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