| Salvianolic acid A displays cardioprotective effects in in vitro models of heart hypoxia/reoxygenation injury. | |
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MedLine Citation:
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PMID: 20924904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress induced by overproduction of reactive oxygen species (ROS) plays an important role in hypoxia/reoxygenation (H/R) injury. In the present study, effects of salvianolic acid A (1) on heart H/R injury through its antioxidant activity were examined, using a molecule-based ROS scavenging system and cardiomyocyte model of H/R injury, as well as isolated rat heart model. As a result, 1 showed a potent antioxidant activity, scavenging all of the tested ROS and DPPH (2,2-diphenyl-1-picrylhydrazyl). The antioxidant effect of 1 was also observed in cardiomyocytes exposed to H/R. Compound 1 remarkably decreased dihydroethidium and dichlorofluorescein fluorescence and increased cell viability and mitochondrial membrane potential, ΔΨ(m), when compared to the H/R group. In isolated rat hearts exposed to H/R, 1 markedly increased the coronary flow, the peak of pressure development and the valley of pressure development, and significantly reduced the left ventricular end diastolic pressure when compared to the H/R group. These results suggested that 1 had significant protective effects against H/R-induced myocardial injury through its antioxidant activity. |
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Authors:
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Yu-Qin Zhang; Yue Tang; Ai-li Wu; Hai-Bo Zhu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of Asian natural products research Volume: 12 ISSN: 1477-2213 ISO Abbreviation: J Asian Nat Prod Res Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-06 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888334 Medline TA: J Asian Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 899-915 Citation Subset: IM |
Affiliation:
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Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / chemically induced, metabolism Biphenyl Compounds / pharmacology Caffeic Acids / chemistry, pharmacology* Cardiotonic Agents / chemistry, pharmacology* Disease Models, Animal Heart / drug effects* Lactates / chemistry, pharmacology* Molecular Structure Myocytes, Cardiac / drug effects Oxidative Stress / drug effects Picrates / pharmacology Rats Reactive Oxygen Species / metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Biphenyl Compounds; 0/Caffeic Acids; 0/Cardiotonic Agents; 0/Lactates; 0/Picrates; 0/Reactive Oxygen Species; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 96574-01-5/salvianolic acid A |
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