| Salvage of circulating pyrimidine nucleosides in the rat. | |
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MedLine Citation:
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PMID: 7248957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new procedure was developed to measure uridine and cytidine in plasma. These nucleosides are present in micromolar concentrations in the plasma of rats, mice, and humans. Inhibitors of pyrimidine synthesis de novo (pyrazofurin or N-phosphonacetyl-L-aspartate) produce only modest decreases in the concentration of circulating uridine or cytidine in the rat. Since both uridine and cytidine are rapidly cleared from the circulation of the rat, constant infusions of radiolabeled uridine and cytidine were used to establish a steady-state specific activity of circulating nucleoside without altering the normal endogenous concentration. These studies permitted an estimation of the contribution of circulating pyrimidine nucleoside to the nucleotide pools of various rat tissues. Most of the uridine entering the circulation (greater than 70%) is catabolized rather than salvaged by formation of nucleotides. Cytidine in the circulation is much more efficiently utilized and is predominantly salvaged. The implication of these results for chemotherapy based on inhibition of pyrimidine synthesis de novo is discussed. |
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Authors:
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J D Moyer; J T Oliver; R E Handschumacher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer research Volume: 41 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-09-25 Completed Date: 1981-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3010-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimetabolites, Antineoplastic / pharmacology Aspartic Acid / analogs & derivatives, pharmacology Cytidine / metabolism Male Phosphonoacetic Acid / analogs & derivatives, pharmacology Pyrimidine Nucleosides / blood, metabolism* Pyrimidine Nucleotides / metabolism Rats Ribonucleosides / pharmacology Tissue Distribution Uridine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 0/Pyrimidine Nucleosides; 0/Pyrimidine Nucleotides; 0/Ribonucleosides; 30868-30-5/pyrazofurin; 4408-78-0/Phosphonoacetic Acid; 51321-79-0/NSC 224131; 56-84-8/Aspartic Acid; 58-96-8/Uridine; 65-46-3/Cytidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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